女性健康研究:一项关于小剂量阿司匹林在癌症初级预防中作用的随机对照试验

作     者：Cook N. R. Lee I. -M. Gaziano J. M. 杜媛 

作者机构：Department of Medicine Brigham and Women's Hospital Harvard Medical School 900 Commonwealth Ave E Boston MA 02215 United States 

出 版 物：《世界核心医学期刊文摘（心脏病学分册）》 (Digest of the World Core Medical Journals(Cardiology))

年 卷 期：2005年第1卷第12期

页      面：19-20页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：初级预防 女性健康 随机对照试验 结肠直肠癌 疾病病史 肺癌死亡率 次要终点 非黑色素皮肤癌 结肠息肉 药物预防 

摘      要：Context: Basic research and observational evidence as well as results from trials of colon polyp recurrence suggest a role for aspirin in the chemoprevention of cancer. Objective: To examine the effect of aspirin on the risk of cancer among healthy women. Design, Setting, and Participants: In the Women’s Health Study, a randomized 2×2 factorial trial of aspirin and vitamin E conducted between September 1992 and March 2004, 39 876 US women aged at least 45 years and initially without previous history of cancer, cardiovascular disease, or other major chronic illness were randomly assigned to receive either aspirin or aspirin placebo and followed up for an average of 10.1 years. Intervention: A dose of 100 mg of aspirin(n=19 934) or aspirin placebo(n=19 942) administered every other day. Main Outcome Measures: Confirmed newly diagnosed invasive cancer at any site, except for nonmelanoma skin cancer. Incidence of breast, colorectal, and lung cancer were secondary end points. Results: No effect of aspirin was observed on total cancer(n=2865; relative risk[RR], 1.01; 95%confidence interval[CI], 0.94-1.08; P=.87), breast cancer(n=1230; RR, 0.98; 95%CI, 0.87-1.09; P=.68), colorectal cancer(n=269; RR, 0.97; 95%CI, 0.77-1.24; P=.83), or cancer of any other site, with the exception of lung cancer for which there was a trend toward reduction in risk(n=205; RR, 0.78; 95%CI, 0.59-1.03; P=.08). There was also no reduction in cancer mortality either overall(n=583; RR, 0.95; 95%CI, 0.81-1.11; P=.51) or by site, except for lung cancer mortality(n=140; RR, 0.70; 95%CI, 0.50-0.99; P=.04). No evidence of differential effects of aspirin by follow-up time or interaction with vitamin E was found. Conclusions: Results from this large-scale, long-term trial suggest that alternate day use of low-dose aspirin(100 mg) for an average 10 years of treatment does not lower risk of total, breast, colorectal, or other site-specific cancers. A protective effect on lung cancer or a benefit of higher do