Examining heterogeneity of stromal cells in tumor microenvironment based on pan-cancer single-cell RNA sequencing data

作     者：Wenhui Wang Li Wang Junjun She Jun Zhu Wenhui Wang;Li Wang;Junjun She;Jun Zhu

作者机构：Department of Genetics and Genomic SciencesIcahn School of Medicine at Mount SinaiNew YorkNY 10029USA Sema4a Mount Sinai ventureStamfordCT 06902USA First Affiliate Hospital of Xi’an Jiaotong UniversityXi’an 710061China Tisch Cancer InstituteIcahn School of Medicine at Mount SinaiNew YorkNY 10029USA 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2022年第19卷第1期

页      面：30-42页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：partially supported by NIH grants(Grant Nos.R01CA249175 and U19AI118610)。 

主　　题：Stromal cells tumor microenvironment pan-cancer single-cell RNA sequencing data 

摘      要：Tumor tissues contain both tumor and non-tumor cells,which include infiltrated immune cells and stromal cells,collectively called the tumor microenvironment(TME).Single-cell RNA sequencing(sc RNAseq)enables the examination of heterogeneity of tumor cells and TME.In this review,we examined sc RNAseq datasets for multiple cancer types and evaluated the heterogeneity of major cell type composition in different cancer types.We further showed that endothelial cells and fibroblasts/myofibroblasts in different cancer types can be classified into common subtypes,and the subtype composition is clearly associated with cancer characteristic and therapy response.