Hematological changes during androgen deprivation therapy

作     者：Mathis Grossmann Jeffrey D Zajac 

作者机构：Department of Medicine Austin Health/Northern Health University of Melbourne Heidelberg Vic. 3084 Australia 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2012年第14卷第2期

页      面：187-192页

核心收录：

学科分类：0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 071010[理学-生物化学与分子生物学] 1002[医学-临床医学] 07[理学] 08[工学] 083203[工学-农产品加工及贮藏工程] 

基　　金：Support from the National Health and Medical Research Council of Australia The Royal Australasian College of Physicians 

主　　题：anemia androgen deprivation therapy （ADT） prostate cancer 

摘      要：Androgen deprivation therapy （ADT） has been associated with a plethora of adverse effects, consistent with the androgen dependency of multiple reproductive and somatic tissues. One such tissue is the hemopoietic system, and one of the most predictable consequences of ADT is the development of anemia. Although anemia caused by ADT is rarely severe, ADT is often given to frail, elderly men with increased susceptibility to anemia due to multiple other causes. ADT-associated anemia may contribute to fatigue and reduced quality of life （QoL） in such men, although this requires further study. While anemia is an independent risk factor of mortality in men with prostate cancer, it is not known whether treatment of ADT-associated anemia alters clinically important outcomes, or whether treatment affects mortality. Awareness of the phenomenon of ADT-induced anemia should avoid unnecessary work-up in mild cases of normocytic normochromic anemia. However, assessment and treatment of more severe anemia may be required. This should be determined on an individual basis. In contrast to the weli-descrihed actions of ADT on erythropoiesis, its effect on other hemopoietic lineages has been less well elucidated. While preclinical studies have found roles for androgens in maturation and differentiated function of neutrophils, lymphocytes and platelets, the implications of these findings for men with prostate cancer receiving ADT require further studies.