Effects of Eriobotrya japonica(Lindl.) flower extracts on mercuric chloride-induced hepatotoxicity in rats

作     者：ESMAEILI Amir Hossein KHAVARI-NEJAD Ramazan Ali HAJIZADEH MOGHADDAM Akbar CHAICHI Mohammad Javad EBRAHIMZADEH Mohammad Ali 

作者机构：Department of BiologyScience and Research BranchIslamic Azad UniversityBox 14515-775TehranIran Faculty of Basic ScienceUniversity of MazandaranBox 47416-95448BabolsarIran Faculty of ChemistryUniversity of MazandaranBox 47416-95447BabolsarIran Pharmaceutical Sciences Research CenterSchool of PharmacyMazandaran University of Medical SciencesSari 48189Iran 

出 版 物：《Chinese Science Bulletin》 (Chinese Science Bulletin)

年 卷 期：2012年第57卷第30期

页      面：3891-3897页

核心收录：

学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学] 

主　　题：氯化汞 大鼠肝 提取物 枇杷 诱导 火焰原子吸收光谱法 总抗氧化能力 化学动力学模型 

摘      要：Mercury(II) is an important factor in hepatotoxicity that can enter the body through marine diets and *** the present study,the protective effect of the Eriobotrya japonica flower extract(EJFE) on HgCl 2-induced hepatotoxicity was *** mg/kg of mercuric chloride in drinking water was given to rats either with saline or EJFE(100 and 200 mg/kg as intraperitoneal(IP)) for 30 *** mercury levels in different groups of liver tissues of the rats were measured with flameless atomic absorption spectroscopy(F-AAS).Also,mercury accumulation in the liver of the rats was modeled by using a parallel chemical kinetic *** results showed that HgCl 2-induced oxidative damage led to a significant decrease in glutathione(GSH) and the total antioxidant capacity(TAC) levels,and to a significant increase in lipid peroxidation *** mercury was 14.47% more in the livers of the stress groups than in those of the control groups(P0.001),whereas the amount of Hg was adjusted to 13.49% and 13.93% in groups treated with 100 and 200 mg/kg of EJFE respectively,as compared with stress groups(P0.001).HPLC analysis of EJFE revealed that hesperetin and gallic acid are the major antioxidants in *** demonstrate that flowers of the Eriobotrya japonica cause a significant protection against HgCl 2 induced hepatotoxicity in all diagnostic parameters by strengthening the antioxidant defense mechanisms and they may have a therapeutic function in free radical mediated diseases.