Diagnostic imaging, preautopsy imaging and autopsy findings of 8 AIDS cases： a comparative study
Diagnostic imaging, preautopsy imaging and autopsy findings of 8 AIDS cases： a comparative study作者机构：Department of Radiology First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China Therapeutic Centre for AIDS and Sexually Transmitted Diseases Affiliated You'an Hospital Capital Medical University Beijing 100054 China Center for Diagnostic Medical Imaging Nanfang Hospital Southern Medical University Guangzhou Guangdong 510515 China
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2009年第122卷第18期
页 面：2142-2148页
核心收录：
学科分类：04[教育学] 1002[医学-临床医学] 08[工学] 0838[工学-公安技术]
基 金：Scientific and Technological Funds for Key Medical Issues [2008ZX 10001-006]
主 题：AIDS pathology diagnostic imaging autopsy
摘 要：Background Aquired immune deficiency syndrome （AIDS） presents a challenge to medical researchers because of its unique pathological and clinical picture. The clinical data, particularly autopsy evidence, from China have failed to provide enough pathological and etiological evidence for AIDS diagnosis, which impairs the reliability of the diagnosis and our full understanding of the occurrence and development of AIDS complications. The purpose of this study was to investigate the imaging and pathologic characteristics of AIDS. Methods Autopsy, imaging and pathological data from 8 cases of AIDS were retrospectively analyzed. Routine CT scanning of different body parts was performed during their periods of hospitalization. Transverse CT scanning was conducted from the skull to the pelvis immediately after the occurrence of death. After routine formalin fixing, 7 cardevers were cross sectioned for autopsy in freezing state and 1 for gross autopsy. Tissues were obtained from each section and organs for pathological examinations. Results The autopsy data indicated the presence of parasitic infections, bacterial infections, fungal infections, and virus infections in AIDS patients. Pneumocystis pneumonia, pulmonary tuberculosis, coccobacteria pneumonia, Aspergillus pneumonia, cytomegaJovirus pneumonia, toxoplasma encephalitis, lymphoma and cerebrovascular diseases were found in these patients. Conclusions During the course of AIDS progression, the concurrent multiple infections as well as tumor development may resuJt in multiple organ pathological changes and clinically complex symptoms that further complicate the imaging and pathological manifestations, thus resulting in difficult differential diagnosis. A combination of imaging data and autopsy data can help to clarify the diagnosis.
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