Immune response to SARS-CoV-2 in children: A review of the current knowledge

作     者：Filippos Filippatos Elizabeth-Barbara Tatsi Athanasios Michos Filippatos Filippos;Tatsi Elizabeth-Barbara;Michos Athanasios

作者机构：First Department of PediatricsInfectious Diseases and Chemotherapy Research LaboratoryMedical SchoolNational and Kapodistrian University of Athens“Aghia Sophia”Children’s HospitalAthensGreece 

出 版 物：《Pediatric Investigation》 (儿科学研究（英文）)

年 卷 期：2021年第5卷第3期

页      面：217-228页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：SARS-CoV-2 COVID-19 Immunity Multisystem inflammatory syndrome Children 

摘      要：Host immune responses to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),especially in children,are still under investigation.Children with coronavirus disease 2019(COVID-19)constitute a significant study group of immune responses as they rarely present with severe clinical manifestations,require hospitalization,or develop complications such as multisystem inflammatory syndrome in children(MIS-C)associated with SARS-CoV-2 infection.The deciphering of children’s immune responses during COVID-19 infection will provide information about the protective mechanisms,while new potential targets for future therapies are likely to be revealed.Despite the limited immunological studies in children with COVID-19,this review compares data between adults and children in terms of innate and adaptive immunity to SARS-CoV-2,discusses the possible reasons why children are mostly asymptomatic,and highlights unanswered or unclear immunological issues.Current evidence suggests that the activity of innate immunity seems to be crucial to the early phases of SARS-CoV-2 infection and adaptive memory immunity is vital to prevent reinfection.