Wendan decoction improves learning and memory deficits in a rat model of schizophrenia

作     者：Cuiping Yang Changchun Cai Xiaojin Yang Yanping Yang Zhigang Zhou Jianhua Liu Heping Ye HongjiaoWan 

作者机构：Jiangxi University of Traditional Chinese Medicine Nanchang 330004 Jiangxi Province China Affiliated Hospital of Jiujiang University of Jiangxi Province Jiujiang 332000 Jiangxi Province China Grade 2010 Postgraduate Medical School of Nanchang University Nanchang 330006 Jiangxi Province China Grade 2010 Postgraduate Xuzhou Medical College Xuzhou 221004 Jiangsu Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2012年第7卷第15期

页      面：1132-1137页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0905[农学-畜牧学] 09[农学] 090501[农学-动物遗传育种与繁殖] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：sponsored by the Natural Science Foundation of China (No. 81160423) Research Plan of Traditional Chinese Medicine of Jiangxi Province Department of Public Health (No. 2009A054) Jiangxi Provincial Youth Science Fund Project (No. GJJ11190) 

主　　题：Wendan decoction schizophrenia Morris water maze long-term potentiation hippocampus learning and memory traditional Chinese medicine neural regeneration 

摘      要：An experimental model of schizophrenia was established using dizocilpine （MK-801）. Rats were intragastrically administered with Wendan decoction or clozapine for 21 days prior to establishing the model. The results revealed that the latency of schizophrenia model rats to escape from the hidden platform in the Morris water maze was significantly shortened after administration of Wendan decoction or clozapine. In addition, the treated rats crossed the platform significantly more times than the untreated model rats. Moreover, the rate of successful long-term potentiation induction in the Wendan decoction group and clozapine group were also obviously increased compared with the model group, and the population spike peak latency was significantly shortened. These experimental findings suggest that Wendan decoction can improve the learning and memory ability of schizophrenic rats to the same extent as clozapine treatment.