T cell immune responses to SARS-CoV-2 and variants of concern(Alpha and Delta)in infected and vaccinated individuals

作     者：Stanley C.Jordan Bong-Ha Shin Terry-Ann M.Gadsden Maggie Chu Anna Petrosyan Catherine N.Le Rachel Zabner Jillian Oft Isabel Pedraza Susan Cheng Ashley Vo Noriko Ammerman Jasmine Plummer Shili Ge Max Froch Anders Berg Mieko Toyoda Ruan Zhang 

作者机构：Comprehensive Transplant CenterTransplant Immunology LaboratoryCedars-Sinai Medical CenterLos AngelesCAUSA Division of Infectious DiseasesCedars-Sinai Medical CenterLos AngelesCAUSA Department of CardiologyCedars-Sinai Medical CenterLos AngelesCAUSA Department of Bioinformatics&Functional GenomicsCedars-Sinai Medical CenterLos AngelesCAUSA Department of Pathology&Laboratory MedicineCedars-Sinai Medical CenterLos AngelesCAUSA 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2021年第18卷第11期

页      面：2554-2556页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：derived entirely from internal resources at Cedars-Sinai Medical Center including funding from the Borstenin Family Foundation Los Angeles 

主　　题：Alpha infected immunity 

摘      要：Our understanding of immune responses to SARS-CoV-2 and variants of concern(VOCs)has been primarily acquired through analysis of Spike-specific IgG responses.However,a more comprehensive understanding of the breadth and longevity of immune responses after infection and vaccination requires analysis of cellular immunity.Herein,we report on T cell immunity in infected and vaccinated individuals,identifying CD4+/CD8+T cell cytokine responses to SARS-CoV-2 and variant peptides(Alpha,B.1.1.7 and Delta,B.1.617.2).