Antibacterial ability and biocompatibility of fluorinated titanium by plasma-based surface modification

作     者：Mian Chen Xiao-Qiao Wang Er-Lin Zhang Yi-Zao Wan Jian Hu Mian Chen;Xiao-Qiao Wang;Er-Lin Zhang;Yi-Zao Wan;Jian Hu

作者机构：Jiangxi Key Laboratory of NanobiomaterialsInstitute of Advanced MaterialsEast China Jiaotong UniversityNanchang 330013China Key Laboratory for Anisotropy and Texture of Materials(ATM)School of Material Science and EngineeringNortheastern UniversityShenyang 110819China 

出 版 物：《Rare Metals》 (稀有金属（英文版）)

年 卷 期：2022年第41卷第2期

页      面：689-699页

核心收录：

学科分类：080503[工学-材料加工工程] 08[工学] 0806[工学-冶金工程] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学] 

基　　金：This study was financially supported by the National Natural Science Foundation of China(No.52001122,51801064 and 51961012) Jiangxi Outstanding Young Talents Program(No.20192BCB23014),and Jiangxi Key Research and Development Program(No.20203BBE53050). 

主　　题：Titanium Plasma-based technology Fluorine Antibacterial property Cytocompatibility 

摘      要：Biomaterial surfaces with satisfied antibacterial activity and appropriate cytocompatibility are a pressing clinical need for orthopedic and dental implants.Fluorinecontaining biomaterials have been demonstrated to obtain antibacterial activity and osteogenic property,while the effect of fluorine chemical compositions on antibacterial property and cytocompatibility is rarely studied.To this end,the coatings with different fluorine chemical compositions on titanium surface were prepared by plasma treatment to verify the antibacterial ability and cytocompatibility of fluorinated surfaces.Their antibacterial ability was evaluated by using Staphylococcus aureus,and the cell compatibility was investigated with MC3T3-E1 cells in vitro.The results show that both fluorocarbon coating and metal fluorides coating exhibited a hydrophilic and nano-scaled roughness.Rather than the fluorocarbon coating,the coating composed of metal fluorides presented satisfied bactericide effect and excellent cytocompatibility.The antibacterial mechanism is associated with the metal fluorides and released fluoride ion.This work would provide novel sight in optimizing the surface modification method of fluorinated biomaterials for biomedical applications.