Hyphenated Techniques in Liquid Chromatography and their Applications in Forensic Toxicology:A Review

作     者：Sachil Kumar Maciej J.Bogusz 

作者机构：Department of Forensic SciencesNaif Arab University for Security Sciences College of Criminal JusticeNaif Arab University for Security Sciences Royal Clinics King Faisal Specialist Hospital and Research CentreRoyal Toxicological LaboratoryRiyadhSaudi Arabiainstitute of Forensic MedicineAachen University of TechnologyAachenGermany 

出 版 物：《Journal of Forensic Science and Medicine》 (法庭科学与法医学杂志（英文）)

年 卷 期：2021年第7卷第4期

页      面：123-136页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Chemical warfare agents chromatography drug abuse forensic toxicology hazardous substances high-pressure liquid mass spectrometry 

摘      要：Conventional analytical methods,such as gas chromatography,high performance liquid chromatography(LC),ultra-violet,and others,are ineffective in addressing the increasing number of problems in forensic *** analytical methods,wherein the separation method are coupled or combined with spectral methods,with the help of a proper interface,are the available alternative *** key benefits of these methods are the requisites of low limits for detection,shorter analytical time,the possibility of automation,better reproducibility,and high precision and *** review discusses on some of the hyphenated analytical methods that involve LC as the separation tool,for their most recent applications in the area of forensic toxicology focusing on the screening of drugs of abuse,the usage of alternative matrices for monitoring drug abuse,analysis of chemical warfare agents,determination of doping agents and related substances,natural toxins,environmental poisons,and examination of food produce *** incorporation of the more user-friendly LC-interfaces,such as atmospheric pressure chemical ionization,and electrospray ionization in the LC-mass spectrometry has increased the popularity of this technique tremendously among scientists of different *** approaches have extremely low constraints regarding the identification and quantification,and offer high reproducibility,with unparalleled potential.