KIF18A is a potential prognostic factor and promotes tumor progression in oral tongue squamous cell carcinoma

作     者：XIAOFEI LV XI YU JIE XU MINGYI WANG CHENG PENG 

作者机构：Department of Stomatologythe Second Hospital of Tianjin Medical UniversityTianjin300211China Department of Anesthesiologythe Second Hospital of Tianjin Medical UniversityTianjin300211China Key Laboratory of Cancer Prevention and TherapyNational Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin300060China Department of Oral&Maxillofacial-Head&Neck OncologyShanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiaotong UniversityShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyNational Clinical Research Center of StomatologyShanghai200011China 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2022年第46卷第5期

页      面：1189-1196页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：KIF18A Tongue cancer Squamous cell carcinoma Progression 

摘      要：The kinesin family member 18A protein was dysregulated in several human cancers and involved in cancer ***,the significance in oral tongue squamous cell carcinoma(OTSCC)has not been *** present study was intended to explore the functions of KIF18A in oral tongue squamous cell *** immunohistochemistry(IHC)assay was performed to assess the relationships between the KIF18A protein expression level and clinical-pathological features of the *** biological functions of KIF18A in OTSCC cells were investigated by the experiments in vitro and in *** on immunohistochemistry,we found that KIF18A was correlated with the clinical-pathological features of OTSCC *** expression of KIF18A was associated with the lymph node metastasis,and clinical *** vitro experiments revealed that silencing of KIF18A significantly inhibited the expression of the proliferation and migration related proteins such as Ki67,proliferating cell nuclear antigen,matrix metalloproteinase-7 and matrix metalloproteinase-9,and thereby inhibiting the proliferation,migration and invasion of tumor *** vivo,knocking-down of KIF18A could inhibit the tumor growth in nude *** conclusion,we found KIF18A promoted tumor progression in vivo and in vitro and might become an effective target for the treatment of OTSCC.