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Antimicrobial Effects of Gatifloxacin on Canine Periodontopathic Bacteria In Vitro

Antimicrobial Effects of Gatifloxacin on Canine Periodontopathic Bacteria In Vitro

作     者:Tadashi Miura Yukari Oda Koji Tanabe Yasuhiko Shizawa Taichi Ito Longqiang Yang Tadashi Miura;Yukari Oda;Koji Tanabe;Yasuhiko Shizawa;Taichi Ito;Longqiang Yang

作者机构:Oral Health Science Center Tokyo Dental College Tokyo Japan Department of Oral and Maxillofacial Implantology Tokyo Dental College Tokyo Japan Department of Biomedical Engineering Iwate Medical University Iwate Japan Department of Liberal Arts College of Bioresource Sciences Nihon University Kanagawa Japan Department of Pediatric Dentistry Sichuan Hospital of Stomatology Chengdu China 

出 版 物:《Journal of Biomedical Science and Engineering》 (生物医学工程(英文))

年 卷 期:2022年第15卷第2期

页      面:89-96页

学科分类:0906[农学-兽医学] 09[农学] 

主  题:Periodontal Disease Antibiotics Dog Porphyromonas gulae Veterinary Medicine 

摘      要:The aim of this study was to identify the potential antibacterial effects of gatifloxacin on one of canine periodontal pathogens, Porphyromonas gulae. The minimum inhibitory concentrations (MIC) of gatifloxacin and its bactericidal effects were investigated. Gatifloxacin inhibited the growth of the canine periodontopathic bacteria tested in broth. An MIC of 50 nM was found to be effective in inhibiting P. gulae. On performing adenosine triphosphate bioluminescence assay, gatifloxacin was found to exhibit bactericidal effects on the tested bacteria in a concentration-dependent manner. The safety of gatifloxacin in mammalian cells was evaluated by assessing the viability of rat bone marrow mesenchymal stem (BMMS) cells treated with gatifloxacin. Almost over 80% of BMMS cells survived after a 3-day culture when treated with 100 nM of gatifloxacin. These results indicate that locally administered gatifloxacin has the potential for being used to prevent canine periodontal infection.

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