Expedient Trifluoromethylacylation of Styrenes Enabled by Photoredox Catalysis
作者机构：Technical Institute of Fluorochemistry(TIF)Institute of Advanced Synthesis(IAS)School of Chemistry and Molecular EngineeringNanjing Tech University30 South Puzhu RoadNanjingJiangsu 211816China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2022年第40卷第1期
页 面：59-64页
核心收录：
学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学]
基 金：the financial support of the National Natural Science Foundation of China(No.21871138) the"Thousand Talents Plan"Youth Program the"Jiangsu Specially-Appointed Professor Plan" the"Innovation&Entrepreneur-ship Talents Plan".
主 题：Trifluoromethylacylation Alkenes Photocatalysis CF_(3)radical Radical-polar crossover
摘 要：Herein,we disclosed a photoredox enabled protocol for trifluoromethylacylation of styrenes through a radical-carboanion cascade and subsequent oxidation.With a broad range of aldehydes and inexpensive Langlois reagent as acyl and CF3 precursor,respectively,the alkene motif could be readily converted into β-trifluoromethyl ketones in moderate to good yields and with excellent regioselectivity.Besides CF3,di-,mono-and non-fluorinated C-radicals were revealed amenable in this reaction,providing good opportunity for the construction of structurally diverse ketones of interest in pharmaceutical research.Additionally,the utility of this protocol was further demonstrated by successful extension to trifluoromethylarylation and-alkylation by employing arylcyanide or acrylates in place of carbonyls.
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