Green biomanufacturing promoted by automatic retrobiosynthesis planning and computational enzyme design

作     者：Ziheng Cui Shiding Zhang Shengyu Zhang Biqiang Chen Yushan Zhu Tianwei Tan Ziheng Cui;Shiding Zhang;Shengyu Zhang;Biqiang Chen;Yushan Zhu;Tianwei Tan

作者机构：National Energy R&D Center for BiorefineryCollege of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing 100029China 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2022年第35卷第1期

页      面：6-21页

核心收录：

学科分类：0710[理学-生物学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0836[工学-生物工程] 0701[理学-数学] 

基　　金：support from the National Nat-ural Science Foundation of China(U1663227 21861132017 21811530003 21878170). 

主　　题：Biomanufacturing Retrobiosynthesis Computational enzyme design Biobased chemicals 

摘      要：Biomanufacturing,which uses renewable resources as raw materials and uses biological processes to produce energy and chemicals,has long been regarded as a production model that replaces the unsustainable fossil economy.The construction of non-natural and efficient biosynthesis routes of chemicals is an important goal of green biomanufacturing.Traditional methods that rely on experience are difficult to support the realization of this goal.However,with the rapid development of information technology,the intelligence of biomanufacturing has brought hope to achieve this goal.Retrobiosynthesis and computational enzyme design,as two of the main technologies in intelligent biomanufacturing,have developed rapidly in recent years and have made great achievements and some representative works have demonstrated the great value that the integration of the two fields may bring.To achieve the final integration of the two fields,it is necessary to examine the information,methods and tools from a bird’s-eye view,and to find a feasible idea and solution for establishing a connection point.For this purpose,this article briefly reviewed the main ideas,methods and tools of the two fields,and put forward views on how to achieve the integration of the two fields.