N-nitro-L-arginine Attenuates Morphine and Dihydroetorphine-induced Place Preference in Mice

作     者：万兴旺 黄矛 何雅琴 李万亥 万莉 由振东 路长林 Wan Xingwang;HUANG Mao;He Yaqin;LI Wanhai;Wan Li;You Zhendong;Lu Changlin

作者机构：第二军医大学东方肝胆外科医院国际合作生物信号转导研究中心上海200438 第二军医大学基础医学部新药评价中心上海200433 第二军医大学药学院药理教研室上海200433 第二军医大学长海医院药学部上海200433 第二军医大学基础医学部神经生物学教研室上海200433 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2002年第11卷第4期

页      面：162-165页

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：ThisprojectwassupportedbyGrantofthePLALaboratoryforNewDrugEvaluation (No .96-0 2 ) 

主　　题：Psychical dependence Morphine Dihydroetrophine Nitric oxide 

摘      要：Opiate dependence has become one of the most urgent problems of modernsociety. Opiate dependence involves physical and psychical dependence. Although many addicts can bedetoxified, the relapse ratio of 95% in 5 a demonstrates that opiate psychical dependence is aproblem more troublesome. It has been reported that acute and chronic administration of L- NNA canmarkedly retard the development of tolerance to physical dependence on morphine, and suppress theabstinence syndromes precipitated by naloxone in opiate dependent rodents, and even reverse theexisting morphine tolerance. However, the effect of L-NNA on the positive reinforcement ofpsychically active substances and its possible mechanism have not yet been reported. In presentstudy, the effect of L- NNA en the psychical dependence induced by opiates was evaluated on thebasis of conditioned place preference.