Urinary concentrations of phenols, oxidative stress biomarkers and thyroid cancer: Exploring associations and mediation effects

作     者：Pan-Pan Chen Pan Yang Chong Liu Yan-Ling Deng Qiong Luo Yu Miao Min Zhang Fei-Peng Cui Jia-Yue Zeng Tian Shi Ting-Ting Lu Da Chen Long-Qiang Wang Chun-Ping Liu Ming Jiang Qiang Zeng Pan-Pan Chen;Pan Yang;Chong Liu;Yan-Ling Deng;Qiong Luo;Yu Miao;Min Zhang;Fei-Peng Cui;Jia-Yue Zeng;Tian Shi;Ting-Ting Lu;Da Chen;Long-Qiang Wang;Chun-Ping Liu;Ming Jiang;Qiang Zeng

作者机构：Department of Occupational and Environmental HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Environment and HealthMinistry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Public Health and Preventive MedicineSchool of MedicineJinan UniversityGuangzhou 510632China School of EnvironmentGuangdong Key Laboratory of Environmental Pollution and HealthJinan UniversityGuangzhou 510632China Department of Thyroid and Breast Surgerythe Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Thyroid and Breast SurgeryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China 

出 版 物：《Journal of Environmental Sciences》 (环境科学学报（英文版）)

年 卷 期：2022年第34卷第10期

页      面：30-40页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (No. 81872585) the National Key Research and Development Program of China (No. 2016YFC1302700) 

主　　题：Case-control study Phenols Mediation Oxidative stress Thyroid cancer 

摘      要：Phenols have been shown to influence the cellular proliferation and function of thyroid in experimental models. However, few human studies have investigated the association between phenol exposure and thyroid cancer, and the underlying mechanisms are also poorly understood. We conducted a case-control study by age- and sex-matching 143 thyroid cancer and 224 controls to investigate the associations between phenol exposures and the risk of thyroid cancer, and further to explore the mediating role of oxidative stress. We found that elevated urinary triclosan (TCS), bisphenol A (BPA) and bisphenol S (BPS) levels were associated with increased risk of thyroid cancer (all P for trends 0.05), and the adjusted odds ratios (ORs) comparing the extreme exposure groups were 3.52 (95% confidence interval (CI):2.08, 5.95), 2.06 (95% CI: 1.06, 3.97) and 7.15 (95% CI: 3.12, 16.40), respectively. Positive associations were also observed between urinary TCS, BPA and BPS and three oxidative stress biomarkers measured by 8-hydroxy-2 -deoxyguanosine (8-OHdG), 8-iso-prostaglandin F(8-iso PGF) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA), as well as between urinary 8-iso PGFand HNE-MA and the risk of thyroid cancer. Mediation analysis showed that urinary 8-iso PGFmediated 28.95%, 47.06% and 31.08% of the associations between TCS, BPA and BPS exposures and the risk of thyroid cancer, respectively (all P 0.05). Our results suggest that exposure to TCS, BPA and BPS may be associated with increased risk of thyroid cancer and lipid peroxidation may be an intermediate mechanism. Further studies are warranted to confirm the findings.