Fabrication of titanium-based alloys with bioactive surface oxide layer as biomedical implants:Opportunity and challenges

作     者：Mohamad Rodzi SITI NUR HAZWANI Ling Xin LIM Zainovia LOCKMAN Hussain ZUHAILAWATI Mohamad Rodzi SITI NUR HAZWANI;Ling Xin LIM;Zainovia LOCKMAN;Hussain ZUHAILAWATI

作者机构：Biomaterials Niche Area GroupSchool of Materials and Mineral Resources EngineeringUniversiti Sains MalaysiaEngineering Campus14300 Nibong TebalPenangMalaysia 

出 版 物：《Transactions of Nonferrous Metals Society of China》 (中国有色金属学报（英文版）)

年 卷 期：2022年第32卷第1期

页      面：1-44页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 080503[工学-材料加工工程] 1002[医学-临床医学] 0806[工学-冶金工程] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：funded by the Malaysian Ministry of Higher Education under the Fundamental Research Grant Scheme(Project Code FRGS/1/2018/TK05/USM/01/5) the first author is supported financially by a scholarship from Universiti Sains Malaysia(USM Fellowship) 

主　　题：titanium alloy orthopedic application surface modification TiO_(2)nanotubes 

摘      要：Titanium and its alloys have long been used as implant materials due to their outstanding mechanical properties and apparent *** this,the search for better alloys has continued to be active by researchers and industries alike,as there are still pressing issues that require *** include(1)a large mismatch in the elastic modulus of the implant material,which causes a stress shielding problem;(2)the release of harmful ions from Ti alloys after long-term use;(3)a low bioactivity of the Ti alloy surface,which prolongs the healing *** research has been directed toward finding new generation Ti alloys composed of more biocompatible phases and modifying the surface of Ti alloys from naturally bio-inert to bioactive in order to circumvent the *** review examines recent work reported on the fabrication of Ti alloys,and based on the survey,major characteristics highlighted the importance of elastic modulus and the use of non-toxic metal elements to improve *** terms of surface modification of Ti alloys,numerous studies have found that a nano-scaled surface oxide layer grown on the surface is always beneficial to improving the bioactivity of Ti alloys for rapid recovery after *** comprehensive review focuses on the appropriate phase and composition for new Ti alloys intended for use as biomedical implants,emphasizing both fabrication and surface modification methods.