Fromα-keto acids to nitrile oxides enabled by copper nitrate:a facile access to fused isoxazolines

作     者：Yuping Zhu Tianqi Liu Bingxin Liu Houguang Shi Qitao Tan Bin Xu 

作者机构：Department of ChemistryAffiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai Engineering Research Center of Organ RepairInnovative Drug Research CenterSchool of MedicineShanghai UniversityShanghai 200444China State Key Laboratory of Organometallic ChemistryShanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China 

出 版 物：《Organic Chemistry Frontiers》 (有机化学前沿（英文）)

年 卷 期：2022年第9卷第3期

页      面：676-681页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：This work was supported by the National Natural Science Foundation of China(21871174,22171178,21971159) Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-09-E00008).The authors thank Prof.Chang-Hua Ding and Dr Mingchun Gao for their helpful discussions.Also,many thanks to Ms Jianjian Zha and Mr Shaohang Lu for performing the experiments for the revision 

主　　题：nitrate fused oxides 

摘      要：α-Keto acids were unprecedentedly employed as novel precursors of nitrile oxides on treatment with copper nitrate,which reacted with maleimides via[3+2]dipolar cycloaddition leading to pharmacologically interesting fused *** approach offers a unique strategy and complementary method for the convenient generation of alkyl substituted nitrile oxides.