Effects of surface roughening on antibacterial and osteogenic properties of Ti-Cu alloys with different Cu contents

作     者：Wei Zhang Shuyuan Zhang Hui Liu Ling Ren Qiang Wang Yang Zhang Wei Zhang;Shuyuan Zhang;Hui Liu;Ling Ren;Qiang Wang;Yang Zhang

作者机构：School and Hospital of StomatologyChina Medical UniversityShenyang 110001China Liaoning Provincial Key Laboratory of Oral DiseasesShenyang 110001China Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China 

出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)

年 卷 期：2021年第88卷第29期

页      面：158-167页

核心收录：

学科分类：080503[工学-材料加工工程] 08[工学] 0817[工学-化学工程与技术] 0806[工学-冶金工程] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0802[工学-机械工程] 0801[工学-力学（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：financially supported by the National Key Research and Development Program of China(Nos.2018YFC1106601 and 2016YFC1100601) the LiaoNing Revitalization Talents Program(No.XLYC1807069) the National Natural Science Foundation of China(Nos.51631009 and 31870954) the Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences(No.174321KYSB2018000)。 

主　　题：Ti-Cu Cu contents HF Antibacterial Osteogenesis 

摘      要：In order to reduce implant-related infections and improve early osseointegration,we performed HF+anodic oxidation on the surface of the new antibacterial Ti-Cu alloy to make the titanium-based implants have a micro/submicron structure.On this basis,a series of surface-modified Ti-x Cu alloys with different Cu contents(3,5 and 7 wt%)were fabricated and a comprehensive study was conducted on MC3 T3-E1 cell adhesion,proliferation,apoptosis and its antibacterial activity against Staphylococcus aureus.Results showed that the Ti-x Cu alloys by HF etching+anodized possessed multifunctional characteristics of antibiofilm and antibacterial abilities,excellent biocompatibility and osteogenesis promoting abilities.Increment of Cu content significantly contributed to the antibacterial and osteogenic properties of HF etching+anodized Ti-Cu alloys.Cell proliferation rates of HF etching+anodized Ti-7 Cu alloys were lower than those of Ti-3 Cu and Ti-5 Cu alloys,while the early cell apoptosis rates were higher than Ti-3 Cu and Ti-5 Cu groups.All the above results finally presented that the HF etching+anodized Ti-5 Cu alloy exhibited extremely strong antibacterial properties,good biological compatibility and osteogenic ability,as well as the most excellent ductility and corrosion resistance,providing a great potential application for the future dental implantation.