检索结果-南通市图书馆

Effects of combined chemical design(cu addition) and topographical modification(SLA) of ti-cu/SLA for promoting osteogenic, angiogenic and antibacterial activities

引用

Journal of Materials Science & Technology 2020年第12期47卷 202-215页

作者： Rui Liu Yulong Tang Hui Liu Lilan Zeng Zheng Ma Jun Li Ying Zhao Ling Ren Ke Yang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China Institute of Molecular Medicine State Key Laboratory of Oncogenes and Related GenesShanghai Institute of CancerRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200011China Department of Stomatology General Hospital of Shenyang Military CommandShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China Center for Human tissues and Organs Degeneration Shenzhen Institute of Advanced TechnologyChinese Academy of ScienceShenzhen 518055China

cu has been proved to possess various beneficial biological activities, while sandblasting and acid etching(SLA) is widely used to modify the commercial dental implant in order to improve osseointegration. Based on the above, a novel antimicrobial dental implant material, ti-cu alloy, was treated with SLA, to combine chemical design(cu addition) and topographical modification(SLA). In this work, the effects of SLA treated ti-cu alloys(ti-cu/SLA) on osteogenesis, angiogenesis and antibacterial properties were evaluated from both in vitro and in vivo tests, and ti/SLA and ti-cu(without SLA) were served as control groups. Benefiting by the combined effects of chemical design(cu addition) and micro-submicron hybrid structures(SLA),ti-cu/SLA had significantly improved inhibitory effects on oral anaerobic bacteria(P. gingivalis and S.mutans) and could induce upregulation of osteogenic-related and angiogenic-related genes expression in vitro. More importantly, in vivo studies also demonstrated that ti-cu/SLA implants had wonderful biological performance. In the osseointegration model, ti-cu/SLA implant promoted osseointegration via increasing peri-implant bone formation and presenting good bone-binding, compared to ti/SLA and ti-cu implants. Additionally, in the peri-implantitis model, ti-cu/SLA effectively resisted the bone resorption resulted from bacterial infection and meanwhile promoted osseointegration. All these results suggest that the novel multiple functional ti-cu/SLA implant with rapid osseointegration and bone resorption inhibition abilities has the potential application in the future dental implantation.

关键词： ti-cu SLA Peri-implantitis Osseointegration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimization of mechanical property, antibacterial property and corrosion resistance of ti-cu alloy for dental implant

引用

Journal of Materials Science & Technology 2019年第10期35卷 2336-2344页

作者： Jiewen Wang Shuyuan Zhang Ziqing Sun Hai Wang Ling Ren Ke Yang School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

ti-cu alloys with different cu contents(3, 5 and 7 wt%) were fabricated and studied as novel antibacterial biomaterials for dental application. The ti-cu alloys were annealing treated at different temperatures(740℃, 830℃ and 910℃) in order to obtain three typical microstructures, β-ti + ti2cu, β-ti + transformed α-ti, and transformed α-ti. Mechanical, antibacterial and biocorrosion properties of ti-cu alloys with different microstructures were well analyzed by scanning electron microscopy(SEM),X-ray diffraction(XRD), transmission electron microscopy(TEM), tensile test, electrochemical test and antibacterial test. The results indicated that the ti-cu alloys with microstructure of β-ti + ti2 cu showed the best ductility compared with other ti-cu alloys with microstructures of β-ti + transformed α-ti and complete transformed α-ti, and meanwhile, increase of the cu content significantly contributed to the decreased ductility due to the increasing amount of ti2 cu, which brought both solid solution strengthening and precipitation strengthening. Finally, the ti-5 cu alloy with microstructure of β-ti + ti2 cu exhibited excellent ductility, antibacterial property and corrosion resistance, providing a great potential in clinical application for dental implants.

关键词： ti-cu alloy ti2cu Microstructure cu contents Optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of surface roughening on antibacterial and osteogenic properties of ti-cu alloys with different cu contents

引用

Journal of Materials Science & Technology 2021年第29期88卷 158-167页

作者： Wei Zhang Shuyuan Zhang Hui Liu Ling Ren Qiang Wang Yang Zhang School and Hospital of Stomatology China Medical UniversityShenyang 110001China Liaoning Provincial Key Laboratory of Oral Diseases Shenyang 110001China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

In order to reduce implant-related infections and improve early osseointegration,we performed HF+anodic oxidation on the surface of the new antibacterial ti-cu alloy to make the titanium-based implants have a micro/submicron structure.On this basis,a series of surface-modified ti-x cu alloys with different cu contents(3,5 and 7 wt%)were fabricated and a comprehensive study was conducted on MC3 T3-E1 cell adhesion,proliferation,apoptosis and its antibacterial activity against Staphylococcus aureus.Results showed that the ti-x cu alloys by HF etching+anodized possessed multifunctional characteristics of antibiofilm and antibacterial abilities,excellent biocompatibility and osteogenesis promoting abilities.Increment of cu content significantly contributed to the antibacterial and osteogenic properties of HF etching+anodized ti-cu alloys.Cell proliferation rates of HF etching+anodized ti-7 cu alloys were lower than those of ti-3 cu and ti-5 cu alloys,while the early cell apoptosis rates were higher than ti-3 cu and ti-5 cu groups.All the above results finally presented that the HF etching+anodized ti-5 cu alloy exhibited extremely strong antibacterial properties,good biological compatibility and osteogenic ability,as well as the most excellent ductility and corrosion resistance,providing a great potential application for the future dental implantation.

关键词： ti-cu cu contents HF Antibacterial Osteogenesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

含Mg多孔ti-cu合金的微波烧结构建及抗菌性能

含Mg多孔Ti-Cu合金的微波烧结构建及抗菌性能

引用

ASTF2023（第五届）抗菌科学与技术论坛

作者：徐吉林齐明慧罗军明南昌航空大学材料科学与工程学院

医用钛合金因其优异的综合性能已成为,已成为硬组织修复替代的首选材料,但临床上仍存在弹性模量过高、细菌感染和骨整合不良等问题。结合多孔结构降低弹性模量,cu具有抗菌和Mg具有促成骨特性,本文采用微波烧结协同Mg造孔构建含Mg多孔ti... 详细信息

医用钛合金因其优异的综合性能已成为,已成为硬组织修复替代的首选材料,但临床上仍存在弹性模量过高、细菌感染和骨整合不良等问题。结合多孔结构降低弹性模量,cu具有抗菌和Mg具有促成骨特性,本文采用微波烧结协同Mg造孔构建含Mg多孔ti-cu合金以期同时解决上述问题。结果表明含Mg多孔ti-cu合金主要由α-ti和ticu及少量Mgcu和单质Mg组成。合金的孔隙率和孔径可通过造孔剂Mg粉的含量及粒径进行调控。抗压强度和弹性模量随着孔隙率的增加而降低。合金与金黄色葡萄球菌及大肠杆菌培养24h,抗菌率均能达到99.9%。多孔结构和Mg的释放是合金具有超强抗菌性能的主要原因。合金在37℃的SBF溶液中浸泡7d可诱导出含CO的缺钙磷灰石,呈现出优异的体外生物活性。相对于致密ti-6Al-4V,合金非常有利于成骨细胞的黏着、铺展、增殖及分化,呈现出优异的细胞相容性和生物活性。本文为开发兼具抗菌和成骨的高强度低模量硬组织植入物提供了一种新思路和新方法。

关键词： ti-cu 抗菌性能微波烧结多孔结构成骨性能

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：