Alkyl-modified nucleobases with 6/5/7/5 ring systems from the insect Cyclopelta parva

作     者：Yong-Ming Yan Heng Chen Wen-Long Chen Dai-Wei Wang Li Liao Qing Lu Yong-Xian Cheng 

作者机构：Institute for Inheritance-Based Innovation of Chinese MedicineMarshall Laboratory of Biomedical EngineeringSchool of Pharmaceutical SciencesHealth Science CenterShenzhen UniversityShenzhen 518060PR China Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare ProductsSchool of Life Sciences and Food EngineeringHanshan Normal UniversityChaozhou 521041PR China 

出 版 物：《Organic Chemistry Frontiers》 (有机化学前沿（英文）)

年 卷 期：2022年第9卷第1期

页      面：75-80页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Key Research and Development Program of China(2017YFA0503900) Shenzhen Government’s Plan of Science and Technology(JCYJ20170412110504956) the Shenzhen Fundamental Research Program(JCYJ20200109114225087) the National Science Fund for Distinguished Young Scholars(81525026) the Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products(2021B1212040015) 

主　　题：ring bases structurally 

摘      要：(±)-Cyclopeltains A and B(1 and 2),two pairs of unusual alkylated adenine derivatives,were isolated from the insect Cyclopelta parva and structurally characterized.1 and 2 both possess a 6/5/7/5 ring system arising from the alkylation of N^(7) and N^(10) by a C6 unit and the formation of a furan ring.A plausible biosynthetic pathway for 1 and 2 was *** evaluation of the enantiomers of 1 and 2 revealed that(−)-1 and(+)-2 could inhibit the production of TNF-αand IL-6 and the expression of iNOS,COX-2,and p-NF-κB.