Electroacupuncture treatment improves motor function and neurological outcomes after cerebral ischemia/reperfusion injury

作     者：Si-Si Li Xu-Yun Hua Mou-Xiong Zheng Jia-Jia Wu Zhen-Zhen Ma Xiang-Xin Xing Jie Ma Chun-Lei Shan Jian-Guang Xu Si-Si Li;Xu-Yun Hua;Mou-Xiong Zheng;Jia-Jia Wu;Zhen-Zhen Ma;Xiang-Xin Xing;Jie Ma;Chun-Lei Shan;Jian-Guang Xu

作者机构：School of Rehabilitation ScienceShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and OrthopedicsYueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Center of Rehabilitation MedicineYueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent RehabilitationMinistry of EducationShanghaiChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第7期

页      面：1545-1555页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 100215[医学-康复医学与理疗学] 10[医学] 

基　　金：supported by the National Key R&D Program of China,No.2018YFC2001600(to JGX) the National Natural Science Foundation of China,No.81902301(to JJW) Budgetary Project of Shanghai University of Traditional Chinese Medicine of China,No.2019LK024(to JJW) Intelligent Medical Program of Shanghai(Municipal)Health Commission of China,No.2018ZHYL0216(to CLS) Clinical Science and Technology Innovation Project of Shanghai Shen Kang Hospital Development Center of China,No.SHDC12018126(to CLS) Accelerated the Development of Traditional Chinese Medicine Three-Year Action Plan Project(of Shanghai Health Commission)of China,Nos.ZY(2018-2020)-CCCX-2001-06(to JGX and CLS)and ZY(2018-2020)-CCCX-2004-05(to JGX and CLS)。 

主　　题：brain-derived neurotrophic factor dendritic electroacupuncture ischemia/reperfusion motor function neurite outgrowth inhibitor-A neurological outcomes Nogo receptor synapse tyrosine kinase B 

摘      要：Electroacupuncture(EA)has been widely used for functional restoration after stroke.However,its role in post-stroke rehabilitation and the associated regulatory mechanisms remain poorly understood.In this study,we applied EA to the Zusanli(ST36)and Quchi(LI11)acupoints in rats with middle cerebral artery occlusion and reperfusion.We found that EA effectively increased the expression of brain-derived neurotrophic factor and its receptor tyrosine kinase B,synapsin-1,postsynaptic dense protein 95,and microtubule-associated protein 2 in the ischemic penumbra of rats with middle cerebral artery occlusion and reperfusion.Moreover,EA greatly reduced the expression of myelin-related inhibitors Nogo-A and NgR in the ischemic penumbra.Tyrosine kinase B inhibitor ANA-12 weakened the therapeutic effects of EA.These findings suggest that EA can improve neurological function after middle cerebral artery occlusion and reperfusion,possibly through regulating the activity of the brain-derived neurotrophic factor/tyrosine kinase B signal pathway.All procedures and experiments were approved by the Animal Research Committee of Shanghai University of Traditional Chinese Medicine,China(approval No.PZSHUTCM200110002)on January 10,2020.