Self-anti-angiogenesis nanoparticles enhance anti-metastatic-tumor efficacy of chemotherapeutics

作     者：Jiamao Luo Xinxian Zhong Yingming Peng Chenyuan Hao Xiaomei Liang Yulu Yang Xiubo Shi Xuncai Chen Xiao Yi iaoxuan Li Jianhua Wu Jinheng Li Qian Xiao Chentian Wu b Ruojing Lu b Yao Pan Xuejiao Wang Jun-Bing Fan Yifeng Wang Ying Wang 

作者机构：Department of Obstetrics&GynecologyZhujiang HospitalSouthern Medical UniversityGuangzhou510280China Guangzhou Key Laboratory of Tumor Immunology ResearchCancer Research InstituteSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou510515China Department of Forensic ToxicologySchool of Forensic MedicineSouthern Medical UniversityGuangzhou510515China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第7期

页      面：179-190页

核心收录：

学科分类：1002[医学-临床医学] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by grants from the National Natural Science Foundation of China(No.22075127,81773291,21872158) Frontier Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR110105005) atural Science Foundation of Guangdong Province(2021A1515011638) 

主　　题：self-anti-angiogenesis Nanoparticles Metastatic ovarian cancer VM EDV 

摘      要：Beyond traditional endothelium-dependent vessel(EDV),vascular mimicry(VM)is another critical tumor angiogenesis that further forms in many malignant metastatic ***,the existing anti-angiogenesis combined chemotherapeutics strategies are only efficient for the treatment of EDV-based subcutaneous tumors,but remain a great challenge for the treatment of in situ malignant metastatic tumor associated with EDV and ***,we demonstrate a self-assembled nanoparticle(VE-DDP-Pro)featuring self-anti-EDV and-VM capacity enables to significantly enhance the treatment efficacy of cisplatin(DDP)against the growth and metastasis of ovarian *** VE-DDP-Pro is constructed by patching DDP loaded cRGD-folate-heparin nanoparticles(VE)onto the surface of protamine(Pro)*** demonstrated the self-anti-angiogenesis capacity of VE-DDP-Pro was attributed to VE,which could significantly inhibit the formation of EDV and VM by regulating signaling pathway of MMP-2/VEGF,AKT/mTOR/MMP-2/Laminin and AKT/mTOR/EMT,facilitating chemotherapeutics to effectively suppress the development and metastasis of ovarian ***,combing with the chemotherapeutics effectiveness of DDP,the VE-DDP-Pro can significantly enhance treatment efficacy and prolong median survival of mice with metastatic ovarian *** believe our self-assembled nanoparticles integrating the anti-EDV and anti-VM capacity provide a new preclinical sight to enhance the efficacy of chemotherapeutics for the treatment malignant metastasis tumor.