Transparent photo thermal hydrogels for wound visualization and accelerated healing

作     者：Ge Xie Nuoya Zhou Shuo Du Yujie Gao Huinan Suo Jing Yang Juan Tao Jintao Zhu Lianbin Zhang Ge Xie;Nuoya Zhou;Shuo Dua;Yujie Gao;Huinan Suo;Jing Yang;Juan Tao;Jintao Zhu;Lianbin Zhang

作者机构：Hubei Engineering Research Center for Biomaterials and Medical Protective MaterialsSchool of Chemistry&Chemical EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074China Department of DermatologyUnion HospitalTongji Medical CollegeHUSTWuhan 430022China 

出 版 物：《Fundamental Research》 (自然科学基础研究（英文版）)

年 卷 期：2022年第2卷第2期

页      面：268-275页

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：The authors are thankful to the HUST Analytical and Testing Center for their help with the facilities.We thank the funding support from the National Natural Science Foundation of China(Grant No.52022032) 

主　　题：Photothermal hydrogel Wound healing Transparency Wound visualization Cs_(x)W0_(3)nanorods 

摘      要：Utilizing photothermal hydrogels as a wound dressing is a promising strategy to accelerate wound ***,a photothermal hydrogel has a strong light-absorbing capability,and hence its transparency can be largely sacrificed,which is unbeneficial for the visual monitoring of wound *** remains challenging to balance the trade-off between the photothermal conversion and wound visualization for the photothermal hydrogel ***,a composite photothermal hydrogel film with high transparency is presented for the visual monitor of the wound,which is constructed by incorporating CsxW03 nanorods into the networks of polyacrylamide *** composite photothermal hydrogel film exhibits high light absorption in the near-infrared region and high transmittance in the visible light *** 980 nm laser irradiation,the composite hydrogel can be heated up to 45°*** vivo animal experiment on mouse skin wound model shows that the composite hydrogel film can locally heat the skin wound to accelerate healing while maintaining more than 70%transparency to realize real-time observation of the *** study provides the first attempt to solve the problem of opacity in photothermal hydrogel dressings,promoting the possibility of its clinical applications.