The use of polyisobutylene-based polymers in ophthalmology

作     者：Leonard Pinchuk 

作者机构：Distinguished Research Professor of Biomedical EngineeringUniversity of MiamiBiomedical Engineering Dept.13704 SW 92nd CourtMiami33176FLUnited States Founder and Senior Vice PresidentInnFocusInc.a Santen companyMiamiFLUnited States 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第4期

页      面：185-194页

核心收录：

学科分类：1002[医学-临床医学] 08[工学] 100212[医学-眼科学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 10[医学] 

基　　金：Xi'an Eyedeal Medical Technology Co. Ltd University of Akron, UA 

主　　题：Poly(styrene-block-isobutylene-block-styrene) SIBS Glaucoma MicroShunt Intraocular Lens IOL Polyisobutylene Cataract 

摘      要：A novel polyolefin called poly(styrene-block-isobutylene-block-styrene)(“SIBS)originated from Joseph ***’s laboratory at the University of Akron(Akron,Ohio,United States)and was developed as a biomaterial for long-term implant applications by the *** has no cleavable groups on its backbone or sidechains,is comprised predominantly of alternating secondary and quaternary carbons on its backbone,which prevents embrittlement and cracking under flexion,and undergoes multiple purification steps which renders it extremely biocompatible and well-suited for long-term applications in the *** article explores two ophthalmic devices;1)the PRESERFLO®MicroShunt(Santen Pharmaceutical ***.,Osaka,Japan)made from SIBS that lowers intraocular pressure to thwart progression of vision loss from glaucoma,and 2)a novel intraocular lens(IOL)made from crosslinked polyisobutylene,which is under-development by Xi’an Eyedeal Medical Technology Co.,Ltd.(Xi’an,China)that does not glisten nor cloud over time,as do most conventional IOLs.