铁死亡:免疫细胞及免疫治疗中的璀璨新星

作     者：徐杉 闵军霞 王福俤 Shan Xu;Junxia Min;Fudi Wang

作者机构：The First Affiliated HospitalSchool of Public HealthInstitute of Translational MedicineZhejiang University School of MedicineHangzhou 310058China The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2021年第66卷第22期

页      面：2257-2260,M0003页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(31930057 and 31970689) the National Key Research and Development Program of China(2018YFA0507802 and 2018YFA0507801) the China Postdoctoral Science Foundation(2020TQ0254). 

主　　题：免疫细胞 免疫治疗 death 

摘      要：Ferroptosis is an iron-dependent form of cell death characterized by an accumulation of lipid peroxides.A growing body of recent evidence supports the notion that ferroptosis plays an important role in mediating a wide variety of cellular processes in diseases.Notably,ferroptosis can play a significant role in mediating various functions in immune cells and immunotherapies.Here,we discuss our current understanding regarding the regulatory role of ferroptosis in immune cells,including T cells,B cells,granulocytes,monocytes,and macrophages.In addition,we discuss the general effect of immune cell ferroptosis on human pathophysiology and immunotherapies,thereby suggesting new strategies for targeting ferroptosis in order to modulate the immune system and unravel the mechanisms that underlie ferroptosis in the immune response。