Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease: A Systematic Review and Meta-Analysis

作     者：XIN Qi-qi CHEN Xun YUAN Rong YUAN Ya-hui HUI Jia-qi MIAO Yu CONG Wei-hong CHEN Ke-ji XIN Qi-qi;CHEN Xun;YUAN Rong;YUAN Ya-hui;HUI Jia-qi;MIAO Yu;CONG Wei-hong;CHEN Ke-ji

作者机构：Laboratory of Cardiovascular DiseasesXiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China National Clinical Research Center for Chinese Medicine CardiologyBeijing100091China Department of Clinical LaboratoryXiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2021年第27卷第11期

页      面：858-866页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1005[医学-中医学] 1002[医学-临床医学] 10[医学] 

基　　金：Supported by the Authorized Project of China Academy of Chinese Medical Sciences(No.ZZ13-036-4) the Special Fund of Xiyuan Hospital of China Academy of Chinese Medical Sciences for the Cultivation of the National Natural Science Foundation of China(No.XY20-01)。 

主　　题：coronary heart disease blood stasis syndrome platelet coagulation 

摘      要：Objective To investigate the correlation of platelet and coagulation function with blood stasis syndrome(BSS)in coronary heart disease(CHD).Methods The protocol for this meta-analysis was registered on PROSPERO(CRD42019129452).PubMed,Excerpta Medica Database(Embase),the Cochrane Library,and China National Knowledge Infrastructure(CNKI)were searched from inception to 1st June,2020.Trials were considered eligible if they enrolled BSS and non-BSS(NBSS)patients with CHD and provided information on platelet and coagulation function.The platelet function,coagulation function,and fibrinolytic activity were compared between the BSS and NBSS groups.Forest plots were generated to show the SMDs or ESs with corresponding 95%CIs for each study.Subgroup analysis and sensitivity analysis were performed to explore potential sources of heterogeneity.Results The systematic search identified 1,583 articles.Thirty trials involving 10,323 patients were included in the meta-analysis.The results showed that mean platelet volume,platelet distribution width,platelet aggregation rate,platelet P selectin,fibrinogen,plasminogen activator inhibitor-1(PAI-1),thromboxane B2(TXB2),6-keto-prostaglandin F1alpha(6-keto-PGF1α),and TXB2/6-keto-PGF1αwere higher in the BSS group than in the NBSS group(P0.05 or P0.01).Activated partial thromboplastin time was lower in the BSS group than in the NBSS group in the acute phase of CHD(P0.01).The R and K values in thromboelastography and tissue plasminogen activator(t-PA)and t-PA/PAI-1 were lower in the BSS group than in the NBSS group(all P0.01).No difference was found in the results of platelet count,plateletcrit,maximum amplitude,von Willebrand factor,prothrombin time,thrombin time,international normalized ratio,etc.between groups.Conclusions Increased platelet function,hypercoagulability,and decreased fibrinolytic activity were found among CHD patients with BSS.