Myelin-associated glycoprotein combined with chitin conduit inhibits painful neuroma formation after sciatic nerve transection

作     者：Wei Pi Ci Li Meng Zhang Wei Zhang Pei-Xun Zhang Wei Pi;Ci Li;Meng Zhang;Wei Zhang;Pei-Xun Zhang

作者机构：Department of Orthopedics and TraumaPeking University People’s HospitalPeking UniversityBeijingChina Key Laboratory of Trauma and Neural RegenerationPeking UniversityBeijingChina National Center for Trauma MedicineBeijingChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第6期

页      面：1343-1347页

核心收录：

学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100215[医学-康复医学与理疗学] 100204[医学-神经病学] 10[医学] 

基　　金：the National Natural Science Foundation of China,No.31771322 Major R&D Program of National Ministry of Science and Technology of China,No.2018YFB1105504 Beijing Natural Science Foundation of China,No.7212121 and Shenzhen Science and Technology Plan Project of China,No.JCYJ20190806162205278(all to PXZ) 

主　　题：autotomy axon chitin conduit fibrosis myelin-associated glycoprotein painful neuroma peripheral nerve regeneration 

摘      要：Studies have shown that myelin-associated glycoprotein(MAG)can inhibit axon regeneration after nerve ***,the effects of MAG on neuroma formation after peripheral nerve injury remain poorly *** this study,local injection of MAG combined with nerve cap made of chitin conduit was used to intervene with the formation of painful neuroma after sciatic nerve transfection in *** 8 weeks of combined treatment,the autotomy behaviors were reduced in rats subjected to sciatic nerve transfection,the mRNA expression of nerve growth factor,a pain marker,in the proximal nerve stump was decreased,the density of regenerated axons was decreased,the thickness of the myelin sheath was increased,and the ratio of unmyelinated to myelinated axons was ***,the percentage of collagen fiber area and the percentage of fibrosis marker alpha-smooth muscle actin positive staining area in the proximal nerve stump were *** combined treatment exhibited superior effects in these measures to chitin conduit treatment *** findings suggest that MAG combined with chitin conduit synergistically inhibits the formation of painful neuroma after sciatic nerve transection and alleviates neuropathic *** study was approved by the Animal Ethics Committee of Peking University People’s Hospital(approval No.2019PHE027)on December 5,2019.