Function and regulation of cholecystokinin-octapeptide, β-endorphin and gastrin in anorexic infantile rats treated with ErBao Granules
Function and regulation of cholecystokinin-octapeptide, β-endorphin and gastrin in anorexic infantile rats treated with ErBao Granules作者机构：Yong-Ping Du Jian Shi Shao-Hua Wu Department of Traditional Chinese Medicine Xijing Hospital the Fourth Military Medical University Xi’an 710032 Shaanxi Province China Yue-Ping Zhang Department of Pediatrics Xijing Hospital the Fourth Military Medical University Xi’an 710032 Shaanxi Province China Shou-Chuan Wang Department of Pediatrics Nanjing University of Traditional Chinese Medicine Nanjing 210029 Jiangsu Province China Yong-Ping Du graduated from Shanxi Medical University as a undergraduate and from Nanjing University of Traditional Chinese Medicine as a postgraduate in 1993 attending physician major in gastrointestinal diseases of children having 20 papers published.
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2001年第7卷第2期
页 面：275-280页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
基 金：Project supported by the National Natural Science Foundation of China No.39670896
主 题：anorexia/infancy and childhood sincalide endorphins hypothalamus feeding and eating disorders of childhood gastrins
摘 要：AIM To study the role of cholecystokinin- octapeptide (CCK-8). β-endorphin (β-EP). and gastrin in an anorexic infantile rat model and no subsequent regulation of nose peptides by the Yunpi complex prescription ErBao Granule. METHODS We fed infantile rats with special prepared forage. A liquid extract of ErBao Granule was administered to the rats daily for 3 weeks, CCK-8, β-EP, and gastrin concentrations in hypothalamus, gastric antrum, and plasma of the rats were measured by radioimmunoassay, and were compared with controls. RESULTS Treatment of rats with ErBao Granule inhibited CCK-8 secretion and increased β-EP and gastrin secretion. CCK-8 concentration in hypothalamus and plasma of model control group increased significantly and correlated negatively with food intake of models, respectively. β-EP concentration in gastric antrum and plasma of model control group decreased significantly and showed a positive correlation with food intake of models, respectively. Hypothalamus concentration of β -EP was similar in models and controls. Gastrin concentration in gastric antrum of models was lower than in the blank control group, and correlated positively to food intake of models. Finally, CCK-8 concentrations in plasma of rats showed a positive correlation with plasma β-EP (r=-0.68, P0.05). CONCLUSION The increased plasma and hypothalamus concentration of CCK-8, decreased gastric antrum and plasma level of β -EP, and decreased gastric antrum concentration of gastric are associated significantly with the anorexia of infantile anorexic rat models produced by special forage. ErBao Granule can reverse these changes, which may be the major mechanisms of ErBao Granule simulating feeding.
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