On the ultimate finishing line of the Human Genome Project
作者机构：University of Chinese Academy of SciencesBeijing 100190China The Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China
出 版 物：《The Innovation》 (创新（英文）)
年 卷 期：2021年第2卷第3期
页 面：13-14页
核心收录：
基 金：The authors declare no competing interests.
摘 要：The Human Genome Project(HGP)has paved the way for the Digital Personal Genomes(DPG),whereby a person’s complete genome sequence serves as the primary entry for the Digital Healthcare Systems(DHS).If the goal is to deliver PDG on demand,affordability,mainly the cost,becomes one of the primary issues.However,as a once-in-a-lifetime event,a total cost of US$100 is close to$1 per year contribution.Therefore,what remains is still largely an engineering challenge,since a multi-fold reduction of the current per-genome sequencing cost may be achievable by increasing the scale of operation and the degree of automation over 5–10 years.The second issue is to differentiate scientific achievements from what is applicable to the healthcare systems and human well-being in general.The original thought of HGP is to understand the genetics of cancers—an idea or a proposal was made and debated in the early 1980s,and it is still clear that we need both high-quality genome sequences and time to fully understand their encoded biological information;the success of HGP lies on the separation of these two goals.
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