Antibody Response to COVID-19 Virus--Heilongjiang Province and Gansu Province,China,2020

作     者：Naiying Mao Zhen Zhu Shuangli Zhu Deshan Yu Jun Xu Aili Cui Lei Cao Jinyuan Guo Huiling Wang Dongyan Wang Dongmei Yan Yang Song Qian Yang Zhongyi Jiang Hui Zhang Chang Shu Ming Yang Yanhai Wang Jinbo Xiao Zhenzhi Han Yong Zhang Yan Zhang Wenbo Xu 

作者机构：NHC Key Laboratory of Medical Virology and Viral DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Gansu Provincial Center for Disease Control and PreventionLanzhouGansuChina Heilongjiang Provincial Center for Disease Control and PreventionHaerbinHeilongjiangChina 

出 版 物：《China CDC weekly》 (中国疾病预防控制中心周报（英文）)

年 卷 期：2020年第2卷第34期

页      面：645-650页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by the Key Technologies R&D Program of the National Ministry of Science(2018ZX10713002 and 2018ZX10713001-003) 

主　　题：COV finding fir 

摘      要：What is already known about this topic?Coronavirus disease 2019(COVID-19)has become a global pandemic,while the profile of antibody response against the COVID-19 virus has not been well *** is added by this report?In this study,210 serum samples from 160 confirmed COVID-19 cases with different disease severities were *** IgM,IgA,IgG,and neutralizing antibodies(NAb)against COVID-19 virus were *** findings indicated that four antibodies could be detectable at low levels within 2 weeks of disease onset,then rapidly increasing and peaking from the 3^(rd) to 5^(th) *** decreased between 5^(th) and 9^(th) Weeks,and a higher IgM/IgA level was observed in the groups with mild/moderate severity within 2 weeks(p0.05),while all 4 types of antibodies were higher in the group with severe/critical severity after 4 weeks(p0.05).What are the implications for public health practice?Our study on the dynamics of serological antibody responses against COVID-19 virus among COVID-19 patients complements the recognition regarding the humoral immune response to COVID-19 virus *** findings will help in the interpretation of antibody detection results for COVID-19 patients and be beneficial for the evaluation of vaccination effects.