Effects of electroacupuncture versus nimodipine on long-term potentiation and synaptophysin expression in a rat model of vascular dementia

作     者：Dengming Wei Xuemin Jia Xiangxu Yin Wenwen Jiang 

作者机构：Department of Pathology Medical School of Ningbo University Ningbo 315211 Zhejiang Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第30期

页      面：2357-2361页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：the Natural Science Foundation of Zhejiang Province, No. Y208445 the Natural Science Foundation of Ningbo Science and Technology Bureau, No. 2009A610161 K.C. Wong Magna Fund from Ningbo University 

主　　题：vascular dementia electroacupuncture learning and memory ability long-term potentiation synaptophysin neural regeneration 

摘      要：The present study stimulated Baihui （DU 20） and Dazhui （DU 14） acupoints in a rat model of vascular dementia with electroacupuncture to investigate changes in long-term potentiation and synaptophysin expression in the hippocampus. The results revealed that synaptophysin expression in brain tissues was increased after electroacupuncture. After high4requency stimulation, the population spike latency was shortened and the excitatory postsynaptic potential slope and population spike amplitude were increased. In addition, cognitive function was enhanced, similar to the effects of intragastric perfusion of nimodipine. The results indicated that electroacupuncture at Baihui and Dazhui acupoints can improve learning and memory functions of a rat model of vascular dementia by promoting synaptophysin expression, enhancing hippocampal synaptic plasticity and accelerating synaptic transmission.