Advances in preclinical evaluation of experimental antibody-drug conjugates
作者机构：Cold Spring Harbor LaboratoryCold Spring HarborNY 11724USA
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2021年第4卷第4期
页 面：745-754页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by grants(NIH/NCI RO15R01CA237154-02)-Trotman NIH/NCI CSHL Cancer Center Support Grant 5P30CA45508-33(Tuveson)-Trotman and Lyons the German Research Foundation(DFG)(PL 894/1-1)-Plenker
主 题：Antibody-drug conjugate tumor preclinical organoid CRISPR preclinical imaging theranostic
摘 要：The ability to chemically modify monoclonal antibodies with the attachment of specific functional groups has opened up an enormous range of possibilities for the targeted treatment and diagnosis of cancer in the *** the number of such antibody-based drug candidates has increased,so too has the need for more stringent and robust preclinical evaluation of their in vivo performance to maximize the likelihood that time,research effort,and money are only spent developing the most effective and promising candidate molecules for translation to the *** with the development of antibody-drug conjugate(ADC)technology,several recent advances in preclinical research stand to greatly increase the experimental rigor by which promising candidate molecules can be *** include advances in preclinical tumor modeling with the development of patient-derived tumor organoid models that far better recapitulate many aspects of the human disease than conventional subcutaneous xenograft *** models are amenable to genetic manipulation,which will greatly improve our understanding of the relationship between ADC and antigen and stringently evaluate mechanisms of therapeutic ***,tumor development is often not visible in these in vivo *** discuss how the application of several preclinical molecular imaging techniques will greatly enhance the quality of experimental data,enabling quantitative pre-and post-treatment tumor measurements or the precise assessment of ADCs as effective *** our opinion,when taken together,these advances in preclinical cancer research will greatly improve the identification of effective candidate ADC molecules with the best chance of clinical translation and cancer patient benefit.
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