Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease: A Systematic Review and Meta-Analysis
Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease:A Systematic Review and Meta-Analysis作者机构:Laboratory of Cardiovascular DiseasesXiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China National Clinical Research Center for Chinese Medicine CardiologyBeijing100091China Department of Clinical LaboratoryXiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China
出 版 物:《Chinese Journal of Integrative Medicine》 (中国结合医学杂志(英文版))
年 卷 期:2021年第27卷第11期
页 面:858-866页
核心收录:
学科分类:1007[医学-药学(可授医学、理学学位)] 1005[医学-中医学] 1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金:Supported by the Authorized Project of China Academy of Chinese Medical Sciences(No.ZZ13-036-4) the Special Fund of Xiyuan Hospital of China Academy of Chinese Medical Sciences for the Cultivation of the National Natural Science Foundation of China(No.XY20-01)
主 题:coronary heart disease blood stasis syndrome platelet coagulation
摘 要:Objective To investigate the correlation of platelet and coagulation function with blood stasis syndrome(BSS)in coronary heart disease(CHD).Methods The protocol for this meta-analysis was registered on PROSPERO(CRD42019129452).PubMed,Excerpta Medica Database(Embase),the Cochrane Library,and China National Knowledge Infrastructure(CNKI)were searched from inception to 1st June,*** were considered eligible if they enrolled BSS and non-BSS(NBSS)patients with CHD and provided information on platelet and coagulation *** platelet function,coagulation function,and fibrinolytic activity were compared between the BSS and NBSS *** plots were generated to show the SMDs or ESs with corresponding 95%CIs for each *** analysis and sensitivity analysis were performed to explore potential sources of *** The systematic search identified 1,583 *** trials involving 10,323 patients were included in the *** results showed that mean platelet volume,platelet distribution width,platelet aggregation rate,platelet P selectin,fibrinogen,plasminogen activator inhibitor-1(PAI-1),thromboxane B2(TXB2),6-keto-prostaglandin F1alpha(6-keto-PGF1α),and TXB2/6-keto-PGF1αwere higher in the BSS group than in the NBSS group(P0.05 or P0.01).Activated partial thromboplastin time was lower in the BSS group than in the NBSS group in the acute phase of CHD(P0.01).The R and K values in thromboelastography and tissue plasminogen activator(t-PA)and t-PA/PAI-1 were lower in the BSS group than in the NBSS group(all P0.01).No difference was found in the results of platelet count,plateletcrit,maximum amplitude,von Willebrand factor,prothrombin time,thrombin time,international normalized ratio,*** *** Increased platelet function,hypercoagulability,and decreased fibrinolytic activity were found among CHD patients with BSS.