Mesenchymal stem cells as a potential therapeutic tool to cure cognitive impairment caused by neuroinflammation

作     者：Maryna Skok 

作者机构：Department of Molecular ImmunologyPalladin Institute of Biochemistry NAS of UkraineKyiv 01054Ukraine 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2021年第13卷第8期

页      面：1072-1083页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：Mesenchymal stem cells Neuroinflammation Cognition α7 Nicotinic acetylcholine receptor Extracellular vesicles Alzheimer disease 

摘      要：An established contribution of neuroinflammation to multiple brain pathologies has raised the requirement for therapeutic strategies to overcome it in order to prevent age-and disease-dependent cognitive *** stem cells(MSCs)produce multiple growth and neurotrophic factors and seem to evade immune rejection due to low expression of major histocompatibility complex class I ***,MSCs are widely used in experiments and clinical trials of regenerative *** review summarizes recent data concerning the optimization of MSC use for therapeutic purposes with the emphasis on the achievements of the last 2 *** attention is paid to extracellular vesicles secreted by MSCs and to the role ofα7 nicotinic acetylcholine *** reviewed data demonstrate that MSCs have a significant therapeutic potential in treating neuroinflammation-related cognitive disfunctions including age-related neurodegenerative *** novel data demonstrate that maximal therapeutic effect is being achieved when MSCs penetrate the brain and produce their stimulating factors in ***,therapeutic application using MSCs should include measures to facilitate their homing to the brain,support the survival in the brain microenvironment,and stimulate the production of neurotrophic and anti-inflammatory *** measures include but are not limited to genetic modification of MSCs and pre-conditioning before transplantation.