Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling
作者机构：MOE Key Laboratory of Gene Function and RegulationState Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen University510275 GuangzhouGuangdongChina State Key Laboratory of Respiratory DiseaseGuangzhou Institute of Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical University510182 GuangzhouGuangdongChina Advanced Medical Research InstituteCheeloo College of MedicineShandong University250012 JinanShandongChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2020年第5卷第1期
页 面：646-648页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学]
基 金：supported by National Natural Science Foundation of China(31870862,31700760,31970700,and 31800751) the Fundamental Research Funds for the Central Universities(18lgpy49 and 18lgpy53) National Key Research and Development Program of China(2018YFC1200100) Emergency grants for prevention and control of SARS-CoV-2 from Guangdong Province(2020A111128008) COVID-19 emergency tackling research project of Shandong University(No.2020XGB03).
主 题：acute respiratory death
摘 要：Dear Editor,At present,the world is suffering from an ongoing pandemic of 2019 novel coronavirus(COVID-19)which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2/2019-nCoV).To date,20 million cases were confirmed with a death toll at700,000.Although there are no clinically specific and effective antiviral treatments toward SARS-CoV-2 infection so far,the pathological study of SARS-CoV-2 infection and the development of SARS-CoV-2-specific vaccines are progressing rapidly within these several months.1 However,few reports mentioned the mechanism employed by SARS-CoV-2 for evading from surveillance of immune system.
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