Rapid actions of androgen on PSD95 expression mediated by Ca^(2+)/CaMKI pathway in HT22 cells

作     者：Mi Shixiong Li Sha Zhang Yizhou Chen Meiqin Du J uan Wang Chang Ma Min Cui Huixian 

作者机构：Department of AnatomyHebei Medical UniversityShijiazhuang 050017China 

出 版 物：《解剖学杂志》 (Chinese Journal of Anatomy)

年 卷 期：2021年第44卷第S1期

页      面：77-78页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：expression. stimulation PSD95 

摘      要：The rapid actions of androgen on synaptic plasticity have been extensively ***,the underlying mechanisms remain *** this study,we used mouse hippocampal neuron cell line HT22 cells as a cell research model to investigate whether Ca^(2+)/CaMKII mediates androgen rapid actions on synaptic plasticity,especially for synaptic protein PSD95 *** calcium imaging,we verified incubation with 100 nmol/L testosterone for 20 min had the most significant effect on intracellular Ca^(2+)*** addition,the depolarization of resting membrane potential after testosterone stimulation was observed by patch *** found that the depolarization of resting membrane potential was to-40 mV.