NAD+metabolism:pathophysiologic mechanisms and therapeutic potential
作者机构：State Key Laboratory of Biotherapy and Cancer CenterWest China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China State Key Laboratory of Biotherapy and Cancer CenterWest China Hospitaland Collaborative Innovation Center for BiotherapyChengdu 610041China School of Basic Medical SciencesChengdu University of Traditional Chinese MedicineChengduSichuan 611137China CCU Molecular and Radiation OncologyGerman Cancer Research CenterDepartment of Radiation OncologyHeidelberg University HospitalHeidelbergGermany First Department of MedicineMedical Faculty MannheimUniversity of HeidelbergTheodor-Kutzer-Ufer 1-368167 MannheimGermany West China School of Basic Medical Sciences&Forensic MedicineWest China HospitalSichuan UniversityChengdu 610041China Department of Thoracic Oncology and Department of Radiation OncologyCancer CenterWest China HospitalSichuan UniversityChengdu 610041Chin
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2020年第5卷第1期
页 面：596-632页
核心收录：
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 1002[医学-临床医学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)]
基 金：supported by grants from the National Natural Science Foundation of China(81821002,81790251,81430071,81672381,81972665 and 81772487) Guangdong Basic and Applied Basic Research Foundation(2019B030302012) the National 973 Basic Research Program of China(2013CB911300) the Science and Technology Department of Sichuan Province(No.2017SZ0057,2019YJ0050).
主 题：metabolism therapeutic potential
摘 要：Nicotinamide adenine dinucleotide(NAD^(+))and its metabolites function as critical regulators to maintain physiologic processes,enabling the plastic cells to adapt to environmental changes including nutrient perturbation,genotoxic factors,circadian disorder,infection,inflammation and xenobiotics.These effects are mainly achieved by the driving effect of NAD^(+)on metabolic pathways as enzyme cofactors transferring hydrogen in oxidation-reduction reactions.Besides,multiple NAD^(+)-dependent enzymes are involved in physiology either by post-synthesis chemical modification of DNA,RNA and proteins,or releasing second messenger cyclic ADPribose(cADPR)and NAADP^(+).Prolonged disequilibrium of NAD^(+)metabolism disturbs the physiological functions,resulting in diseases including metabolic diseases,cancer,aging and neurodegeneration disorder.In this review,we summarize recent advances in our understanding of the molecular mechanisms of NAD^(+)-regulated physiological responses to stresses,the contribution of NAD^(+)deficiency to various diseases via manipulating cellular communication networks and the potential new avenues for therapeutic intervention.
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