PDLLA/β-TCP/HA/CHS/NGF Sustained-release Conduits for Peripheral Nerve Regeneration

作     者：YAN Xiumei WANG Jing HE Qundi XU Haixing TAO Junyan KORAL Kelly LI Kebi XU Jingyi WEN Jing HUANG Zhijun XU Peihu 闫秀美;WANG Jing;HE Qundi;徐海星;TAO Junyan;KORAL Kelly;LI Kebi;XU Jingyi;WEN Jing;HUANG Zhijun;许沛虎

作者机构：Department of Pharmaceutical EngineeringSchool of ChemistryChemical Engineering and Life ScienceWuhan University of TechnologyWuhan 430070China China Resources Sanjiu Medical&Pharmaceutical Co.Ltd.Shenzhen 518029China Wuhan Mafangshan Middle SchoolWuhan 430070China Department of PathologyUniversity of Pittsburgh.PittsburghPAUSA 

出 版 物：《Journal of Wuhan University of Technology(Materials Science)》 (武汉理工大学学报（材料科学英文版）)

年 卷 期：2021年第36卷第4期

页      面：600-606页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：Funded by the Chinese National Natural Science Foundation (No. 51572206) the National Innovation and Entrepreneurship Training Program for College (Nos. 202110497032, 202110497033, and S202110497080) 

主　　题：sustained-release composite nerve conduits peripheral nerve regeneration 

摘      要：Using nerve guide conduits (NGCs) to promote the regeneration of PNI is a feasible alternative to *** with NGCs made of single material,composite NGCs have a greater development *** previous research has confirmed that poly(D,L-lactic acid)/β-tricalcium phosphate/hyaluronic acid/chitosan/nerve growth factor (PDLLA/β-TCP/HA/CHS/NGF) NGCs have excellent physical and chemical properties,which can slowly release NGF and support cell adhesion and *** this study,PDLLA/β-TCP/HA/CHS/NGF NGCs were prepared and used to bridge a 10 mm sciatic nerve defect in 200-250 g Sprague-Dawley (SD) rat to verify the performance of the NGCs in *** improvements in nerve regeneration were observed after using the PDLLA/β-TCP/HA/CHS/NGF NGCs based on gross post-operation observation,triceps wet weight analysis and nerve histological *** vivo studies illustrate that the PDLLA/β-TCP/HA/CHS/NGF sustained-release NGCs can effectively promote peripheral nerve regeneration,and the effect is similar to that of autograft.