Wnt8a is one of the candidate genes that play essential roles in the elongation of the seahorse prehensile tail

作     者：Bo Zhang Geng Qin Lili Qu Yanhong Zhang Chunyan Li Chunlei Cang Qiang Lin 

作者机构：CAS Key Laboratory of Tropical Marine Bio-Resources and EcologySouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510275China Institution of South China Sea Ecology and Environmental EngineeringChinese Academy of SciencesGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)Guangzhou 511458China School of Life SciencesUniversity of Science and Technology of ChinaHefei 230026China University of Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Marine Life Science & Technology》 (海洋生命科学与技术（英文）)

年 卷 期：2021年第3卷第4期

页      面：416-426页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071002[理学-动物学] 

基　　金：This work was supported by the K.C.Wong Education Foundation,the National Natural Science Foundation of China(nos.41825013,41706178,41576145,41806189,32000350) the China postdoctoral science foundation grant(no.2019M663151),the Guangdong Special Support Program of Youth Scientific and Technological Innovation(2017TQ04Z269) We are also grateful to Wenqi Hu for help with cell culture 

主　　题：Embryo Seahorse Tail development Wnt8a Wnt gene family 

摘      要：Seahorses are a hallmark of specialized morphological features due to their elongated prehensile ***,the underlying genomic grounds of seahorse tail development remain ***,we evaluated the roles of essential genes from the Wnt gene family for the tail developmental process in the lined seahorse(Hippocampus erectus).Comparative genomic analysis revealed that the Wnt gene family is conserved in *** expression profiles and in situ hybridization suggested that Wnt5a,Wnt8a,and Wnt11 may participate in seahorse tail *** in other teleosts,Wnt5a and Wntll were found to regulate the development of the tail axial mesoderm and tail somitic mesoderm,***,a significantly extended expression period of Wnt8a during seahorse tail development was *** pathway analysis further showed that Wnt5a up-regulated the expression of the tail axial mesoderm gene(Shh),while interaction analysis indicated that Wnt8a could promote the expression of *** summary,our results indicate that the special extended expression period of Wnt8a might promote caudal tail axis formation,which contributes to the formation of the elongated tail of the seahorse.