Augmented renal clearance in Chinese intensive care unit patients after traumatic brain injury: a cross-sectional study

作     者：Zilong Dang Hong Guo Bin Li Maohua Zhen Jian Liu Yuhui Wei Hongyan Qin Zhimin Dou Lei Zhang Lei Zhu Yongqiang Cao Fengjiao Li Xinan Wu Zilong Dang;Hong Guo;Bin Li;Maohua Zhen;Jian Liu;Yuhui Wei;Hongyan Qin;Zhimin Dou;Lei Zhang;Lei Zhu;Yongqiang Cao;Fengjiao Li;Xinan Wu

作者机构：Department of PharmacyThe First Hospital of Lanzhou UniversityLanzhouGansu 730000China Department of Critical Care MedicineThe First Hospital of Lanzhou UniversityLanzhouGansu 730000China Department of NeurosurgeryThe First Hospital of Lanzhou UniversityLanzhouGansu 730000China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第6期

页      面：750-752页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by grants from the Gansu Provincial Department of Education Higher School Innovation Ability Improvement Project(No.2019B-002) the First Hospital of Lanzhou University Hospital Fund(No.ldyyyn2018-04) the Chengguan District Science and Technology Plan Project(No.2020SHFZ0033) the Wu Jie Ping Medical Foundation(No.320.6750.2020-04-42) the Chengguan District Science and Technology Plan Project(No.2017SHFZ0038) 

主　　题：sectional continued clearance 

摘      要：To the Editor:Augmented renal clearance(ARC)refers to an enhanced elimination of circulating solutes,including drugs,by the kidneys at a rate statistically higher than *** the first day of intensive care unit(ICU)admission,ARC occurrence may predict continued creatinine clearance(CrCl)elevation for 1 day to several weeks.[1]ARC has a substantial adverse effect on renally cleared antibiotics pharmacokinetics/*** failure or worse outcomes are more frequent in ARC ***,aone size fits allapproach to drug dosing in ARC patients is inappropriate;dosing requires adjustment for some variables.