Augmented renal clearance in Chinese intensive care unit patients after traumatic brain injury: a cross-sectional study
Augmented renal clearance in Chinese intensive care unit patients after traumatic brain injury: a cross-sectional study作者机构:Department of PharmacyThe First Hospital of Lanzhou UniversityLanzhouGansu 730000China Department of Critical Care MedicineThe First Hospital of Lanzhou UniversityLanzhouGansu 730000China Department of NeurosurgeryThe First Hospital of Lanzhou UniversityLanzhouGansu 730000China
出 版 物:《Chinese Medical Journal》 (中华医学杂志(英文版))
年 卷 期:2022年第135卷第6期
页 面:750-752页
核心收录:
学科分类:1002[医学-临床医学] 100210[医学-外科学(含:普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金:supported by grants from the Gansu Provincial Department of Education Higher School Innovation Ability Improvement Project(No.2019B-002) the First Hospital of Lanzhou University Hospital Fund(No.ldyyyn2018-04) the Chengguan District Science and Technology Plan Project(No.2020SHFZ0033) the Wu Jie Ping Medical Foundation(No.320.6750.2020-04-42) the Chengguan District Science and Technology Plan Project(No.2017SHFZ0038)
主 题:sectional continued clearance
摘 要:To the Editor:Augmented renal clearance(ARC)refers to an enhanced elimination of circulating solutes,including drugs,by the kidneys at a rate statistically higher than *** the first day of intensive care unit(ICU)admission,ARC occurrence may predict continued creatinine clearance(CrCl)elevation for 1 day to several weeks.[1]ARC has a substantial adverse effect on renally cleared antibiotics pharmacokinetics/*** failure or worse outcomes are more frequent in ARC ***,aone size fits allapproach to drug dosing in ARC patients is inappropriate;dosing requires adjustment for some variables.