Nanoengineered polypeptides from tetraphenylethylene-functionalized N-carboxyanhydride: Synthesis, self-assembly and intrinsic aggregation-induced emission

作     者：Xu Wang Zihao Zhao Tianrui Xue Zhengzhong Tan Ziyuan Song Shiqi Wei Yang Bo Ying Wang Jianjun Cheng Xu Wang;Zihao Zhao;Tianrui Xue;Zhengzhong Tan;Ziyuan Song;Shiqi Wei;Yang Bo;Ying Wang;Jianjun Cheng

作者机构：Department of Materials Science and Engineering University of Illinois at Urbana-Champaign Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics) School of Pharmacy Tianjin Medical University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University 

出 版 物：《Progress in Natural Science:Materials International》 (自然科学进展·国际材料(英文))

年 卷 期：2021年第31卷第4期

页      面：541-545页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 10[医学] 

基　　金：support from National Natural Science Foundation of China (No. 21974095) the State Scholarship Fund of China Scholarship Council (No. 201706940015) 

主　　题：N-carboxyanhydride Ring-opening polymerization Polypeptide Micelle Aggregation-induced emission 

摘      要：Ring-opening polymerization of N-carboxyanhydrides(NCAs) bearing pendant groups creates functional polypeptides. In this paper, we report the design, synthesis and polymerization of tetraphenylethylene(TPE)-modified NCA, which is used to incorporate aggregation-induced emission(AIE)-active segments into polypeptides. Specifically, we attempted the synthesis of amphiphilic methoxy poly(ethyleneglycol)-block-poly(γ-benzyl-L-glutamate)-block-poly(γ-4-(1,2,2-triphenylvinyl)benzyl-L-glutamate)(PEG-PBLG-PTPELG), which had well-controlled molecular weight and narrow polydispersity. The hydrophilic PEG and hydrophobic PBLG-PTPELG assembled into micelles in aqueous solution with diameter around 70 nm, displaying AIE at 480 nm. Our work demonstrates that the TPE-modified NCA is applicable for the preparation of the AIE-active polypeptides, integrating the AIE luminogens into the polypeptides which may offer unique opportunities for tuning AIE properties by adjusting the composition and conformation of polypeptides. We preliminarily explored the use of the amphiphilic polypeptides for the formulation of doxorubicin-containing micelles that can potentially be used for real-time monitoring of the nanomedicine distribution.