Novel insights into the pathogenesis of DYT1 dystonia from induced patient-derived neurons

作     者：Baojin Ding Baojin Ding

作者机构：Department of BiologyUniversity of Louisiana at LafayetteLafayetteLAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第3期

页      面：561-562页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by National Institute of Neurological Diseases and Stroke,No.NIH/NINDS NS112910 (to BD) Department of Defense (DoD) Peer Reviewed Medical Research Program (PRMRP) Discovery Award,No.W81XWH2010186 (to BD) 

主　　题：sustained Keller DYT1 

摘      要：Dystonia is a common movement disorder characterized by sustained or intermittent muscle contractions causing abnormal movements and/or postures(Keller Sarmiento and Mencacci,2021).The dystonic syndromes are classified as primary dystonia(dystonia is the only motor feature without tremor) and the secondary dystonia(dystonia is combined with other movement disorders,such as Parkinsonism).