Hypotheses and facts for genetic factors related to severe COVID-19

作     者：Stanislav Vasilev Kotsev Dimitrina Miteva Stanislava Krayselska Martina Shopova Maria Pishmisheva-Peleva Spaska Angelova Stanilova Tsvetelina Velikova 

作者机构：Department of Infectious DiseasesPazardzhik Multiprofile Hospital for Active TreatmentPazardzhik 4400Bulgaria Department of GeneticsSofia University“St.Kliment Ohridski”Sofia 1000Bulgaria Private Practice General PraxisSofia 1113Bulgaria Department of Molecular BiologyImmunology and Medical GeneticsMedical FacultyTrakia UniversityStara Zagora 6000Bulgaria Department of Clinical ImmunologyUniversity Hospital LozenetzSofia 1407Bulgaria Medical FacultySofia University“St.Kliment Ohridski”Sofia 1407Bulgaria 

出 版 物：《World Journal of Virology》 (世界病毒学杂志)

年 卷 期：2021年第10卷第4期

页      面：137-155页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Genome-wide association studies Severe COVID-19 SARS-CoV-2 ACE2 TLR7 ApoE TYK2 OAS DPP9 IFNAR2 CCR2 

摘      要：Genome-wide association analysis allows the identification of potential candidate genes involved in the development of severe coronavirus disease 2019(COVID-19).Hence,it seems that genetics matters here,as ***,the virus s nature,including its RNA structure,determines the rate of mutations leading to new viral strains with all epidemiological and clinical *** these observations,we herein comment on the current hypotheses about the possible role of the genes in association with COVID-19 *** discuss some of the major candidate genes that have been identified as potential genetic factors associated with the COVID-19 severity and infection susceptibility:HLA,ABO,ACE2,TLR7,ApoE,TYK2,OAS,DPP9,IFNAR2,CCR2,*** study of genes and genetic variants will be of great benefit for the prevention and assessment of the individual risk and disease severity in different *** scientific data will serve as a basis for the development of clinically applicable diagnostic and prognostic tests for patients at high risk of COVID-19.