Methyltransferase like 13 mediates the translation of Snail in head and neck squamous cell carcinoma

作     者：Xiaochen Wang Kang Li Yuehan Wan Fangfang Chen Maosheng Cheng Gan Xiong Ganping Wang Shuang Chen Zhi Chen Jianwen Chen Xiuyun Xu Cheng Wang Liang Peng Demeng Chen Xiaochen Wang;Kang Li;Yuehan Wan;Fangfang Chen;Maosheng Cheng;Gan Xiong;Ganping Wang;Shuang Chen;Zhi Chen;Jianwen Chen;Xiuyun Xu;Cheng Wang;Liang Peng;Demeng Chen

作者机构：Center for Translational MedicineInstitute of Precision MedicineThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Oral and Maxillofacial SurgeryHospital of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhouChina Oncology DepartmentChinese PLA General HospitalBeijingChina 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2021年第13卷第3期

页      面：271-281页

核心收录：

学科分类：1003[医学-口腔医学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(81872409) Natural Science Foundation of Guangdong Province(2018A030313610) the Open Funding of the State Key Laboratory of Oral Diseases(SKLOD2021OF02) Guangdong Basic and Applied Basic Research Foundation(2019A1515110110)。 

主　　题：Snail EMT head 

摘      要：Methyltransferase like 13(METTL13),a kind of methyltransferase,is implicated in protein binding and synthesis.The upregulation of METTL13 has been reported in a variety of tumors.However,little was known about its potential function in head and neck squamous cell carcinoma(HNSCC)so far.In this study,we found that METTL13 was significantly upregulated in HNSCC at both mRNA and protein level.Increased METTL13 was negatively associated with clinical prognosis.And METTL13 markedly affected HNSCC cellular phenotypes in vivo and vitro.Further mechanism study revealed that METTL13 could regulate EMT signaling pathway by mediating enhancing translation efficiency of Snail,the key transcription factor in EMT,hence regulating the progression of EMT.Furthermore,Snail was verified to mediate METTL13-induced HNSCC cell malignant phenotypes.Altogether,our study had revealed the oncogenic role of METTL13 in HNSCC,and provided a potential therapeutic strategy.