An efficient non-iterative algorithm to estimate the apparent diffusion coefficient of water molecules in the magnetic resonance diffusion imaging experiments

作     者：Song Gao Fei Wang Dongqi He Shouyu Zhang Shanglian Bao 

作者机构：Department of Physics Health Science Center Peking University Department of Biophysics School of Basic Medical SciencePeking University Medical Physics and Engineer Laboratory School of PhysicsPeking University 

出 版 物：《Chinese Science Bulletin》 (中国科学通报)

年 卷 期：2014年第59卷第8期

页      面：734-739页

核心收录：

学科分类：0809[工学-电子科学与技术（可授工学、理学学位）] 07[理学] 070205[理学-凝聚态物理] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0702[理学-物理学] 

基　　金：partially supported by the National Natural Science Foundation of China(81171330) Beijing Natural Science Foundation(7102102) 

主　　题：表观扩散系数 非迭代算法 磁共振信号 成像实验 水分子 估计 指数衰减 装配过程 

摘      要：Many studies have shown that the magnetic resonance signal decay with an extend range of diffusion weighting(b-factor)is a bi-exponential attenuation in the diffusion-weighted magnetic resonance imaging experiments in *** on this feature and the two-compartmental model,we propose a twice-linear-fitting(TLF)algorithm to estimate the apparent diffusion coefficient(ADC)of the water molecules instead of the commonly used iterative Levenberg–Marquardt(LM)*** TLF algorithm consists of two liner fitting steps to estimate the fast and the slow apparent diffusion coefficients and their sizes,*** is unnecessary to guess the initial values in the whole fitting *** time consumption of the TLF algorithm is much less than that of the iterative LM ***,the TLF algorithm may avoid the extraneous solutions,which often deteriorates the results of the LM *** with the iterative fitting method,the TLF algorithm is a reliable and timeefficient approach to estimate the ADC of water molecules in vivo in magnetic resonance diffusion-weighted imaging experiments.