The Influence of Let-7b-5p Target Gene in Cholangiocarcinoma and its Bioinformatic Analysis

作     者：Xibing Zhang Jianghua Ran Fang Liu Yingpeng Zhao Zongqiang Hu 

作者机构：Department of Hepatopancreatobiliary SurgeryThe First Hospital of KunmingOrgan Transplantation Institute of Yunnan ProvinceYunnan ProvinceChina Department of EndocrineThe First Hospital of KunmingKunming 650000Yunnan ProvinceChina 

出 版 物：《Journal of Clinical and Nursing Research》 (临床护理研究（英文）)

年 卷 期：2021年第5卷第2期

页      面：33-37页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Open project of Yunnan Provincial Organ Transplantation Clinical Medicine Center 2020SYZ-Z-012 

主　　题：Let-7b-5p Cholangiocarcinoma Bioinformatics CXCL8 SDC2 

摘      要：Objective:To analyze the biological functions and its clinical significance of let-7b-5p target gene in cholangiocarcinoma utilizing ***:The paper focuses on the let-7b-5p target gene,and predicts its biological functions as well as related signal pathways through GO biological function and KEGG signal pathway enrichment *** STRING database and Cytoscape are used to construct a protein-protein interaction network to screen core ***:The results of GO analysis showed that let-7b-5p target gene was mainly enriched in biological processes such as Small GTPase binding,Rho GTPase binding,and Rac GTPase *** results of KEGG analysis showed that let-7b-5p target gene was significantly enriched in key signaling pathways including Focal adhesion and ECM-receptor *** protein-protein interaction network and module analysis,CXCL8 and SDC2 were screened as the core ***:let-7b-5p can participate in the regulation of biological functions of tumor cells in cholangiocarcinoma,suggesting that it may play an important role as a tumor suppressor gene and biomarker in the occurrence and development of cholangiocarcinoma,which provides new ideas for its diagnosis and treatment.