Worldwide 1-month case fatality of ischaemic stroke and the temporal trend

作     者：Runhua Zhang Yu Wang Jiming Fang Miaoxin Yu Yongjun Wang Gaifen Liu 

作者机构：Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological DiseasesBeijingChina ICESTorontoOntarioCanada 

出 版 物：《Stroke & Vascular Neurology》 (卒中与血管神经病学（英文）)

年 卷 期：2020年第5卷第4期

页      面：353-360页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the Ministry of Science and Technology of the People’s Republic of China(2017YFC1307702) Capital’s Funds for Health Improvement and Research(2020-1-2041) Beijing Municipal Administration of Hospitals’Sail Plan(XMLX201712). 

主　　题：trend annually assessed 

摘      要：background The 1-month case fatality of ischaemic stroke is an essential epidemiological metric.Whereas the case fatality after ischaemic stroke and the temporal trend is uncertain.We aimed to estimate the 1-month case fatality of ischaemic stroke and its temporal trend,as well as its regional variation.Methods We searched PubMed and Embase to identify the studies for 1-month case fatality of ischaemic stroke.The population-based studies were included.Two investigators extracted the data and assessed the quality independently.One-month case fatality of ischaemic stroke was estimated using a random effects model.The temporal trend was evaluated using a mixed-effect meta-regression model.results A total of 59 articles with 77 time periods were included.The worldwide 1-month case fatality of ischaemic stroke was 13.5%(95%CI 12.3%to 14.7%).The case fatality was 10.8%(95%CI 8.3%to 13.5%)in Asia,14.2%(95%CI 12.6%to 15.9%)in Europe,14.0%(95%CI 11.2%to 17.1%)in South America and Caribbean,14.0%(95%CI 9.5%to 19.1%)in North America and 12.5%(95%CI 11.1%to 13.9%)in Australia and New Zealand.Overall,there was a non-significant decrease of 0.1%per year in case fatality.It decreased significantly in Europe(−0.2%annually,95%CI−0.4%to−0.01%)and North America(−0.2%annually,95%CI−0.4%to−0.04%),increased significantly in Australia and New Zealand(0.2%annually,95%CI 0.1%to 0.4%),while no evidence of change in other regions.Conclusion The 1-month case fatality of ischaemic stroke and its temporal trend were divergent across regions.Further studies are needed to address the reason of the regional difference,which will be helpful to guide the effort of reducing stroke burden.