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Doping effects of manganese on the catalytic performance and structure of NiMgO catalysts for controllabe synthesis of multi-walled carbon nanotubes

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Journal of Energy Chemistry 2014年第6期23卷 781-788页

作者： Maofei Ran Wei Chu Yan Liu Dong Liu Chang Zhang Jiae Zheng College of Chemistry & Environment Protection Engineering Southwest University for Nationalities Institute of Chemical and Engineering Sciences (ices) A*STAR 627833 Singapore College of Chemical Engineering Sichuan University

Doping effects of manganese （Mn） on catalytic performance and structure evolution of NiMgO catalysts for synthesis of multi-walled carbon nanotubes （MWCNTs） from methane were investigated for the first time. Addition of Mn in NiMgO catalyst can greatly improve the MWCNTs yield. Mno.2NiMgO catalyst among the tested ones gives the highest MWCNTs yield as 2244%, which is two times higher than that of the catalyst without Mn. The structure evolution, reduction behaviors and surface chemical properties of MnNiMgO catalysts with various Mn contents were studied in detail. It was found that the stable solid solution of NiMgO2 formed in NiMgO catalyst was disturbed by the addition of Mn. Instead, another solid solution of MnMg608 is formed. More amount of Ni can be reduced and dispersed on the catalyst surface to be acted as active sites. Importantly, the changes of Ni content on the surface are correlated with the Ni particle size and the outer diameter of MWCNTs, suggesting the controllable synthesis of MWCNTs over MnNiMgO catalysts.

关键词： doping effect manganese NiMgO catalyst controllable synthesis carbon nanotubes

Worldwide 1-month case fatality of ischaemic stroke and the temporal trend

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Stroke & Vascular Neurology 2020年第4期5卷 353-360页

作者： Runhua Zhang Yu Wang Jiming Fang Miaoxin Yu Yongjun Wang Gaifen Liu Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina ices TorontoOntarioCanada

background The 1-month case fatality of ischaemic stroke is an essential epidemiological metric.Whereas the case fatality after ischaemic stroke and the temporal trend is uncertain.We aimed to estimate the 1-month case fatality of ischaemic stroke and its temporal trend,as well as its regional variation.Methods We searched PubMed and Embase to identify the studies for 1-month case fatality of ischaemic stroke.The population-based studies were included.Two investigators extracted the data and assessed the quality independently.One-month case fatality of ischaemic stroke was estimated using a random effects model.The temporal trend was evaluated using a mixed-effect meta-regression model.results A total of 59 articles with 77 time periods were included.The worldwide 1-month case fatality of ischaemic stroke was 13.5%(95%CI 12.3%to 14.7%).The case fatality was 10.8%(95%CI 8.3%to 13.5%)in Asia,14.2%(95%CI 12.6%to 15.9%)in Europe,14.0%(95%CI 11.2%to 17.1%)in South America and Caribbean,14.0%(95%CI 9.5%to 19.1%)in North America and 12.5%(95%CI 11.1%to 13.9%)in Australia and New Zealand.Overall,there was a non-significant decrease of 0.1%per year in case fatality.It decreased significantly in Europe(−0.2%annually,95%CI−0.4%to−0.01%)and North America(−0.2%annually,95%CI−0.4%to−0.04%),increased significantly in Australia and New Zealand(0.2%annually,95%CI 0.1%to 0.4%),while no evidence of change in other regions.Conclusion The 1-month case fatality of ischaemic stroke and its temporal trend were divergent across regions.Further studies are needed to address the reason of the regional difference,which will be helpful to guide the effort of reducing stroke burden.

关键词： trend annually assessed

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快速多极方法的概念性介绍

中国科学：数学 2012年第5期42卷 491-500页

作者：应乐兴 Department of Mathematics and ices University of Texas at AustinAustinTXUSA

本文对快速多极方法作一概念性的非严格的描述,该方法用来评估具有源分布的卷曲核函数.我们分别考虑了非振动核情形以及振动核情形.对于非振动核情形,我们概述了由Greengard和Rokhlin提出的经典快速多极方法的主要思想.对于振动核情形,... 详细信息

本文对快速多极方法作一概念性的非严格的描述,该方法用来评估具有源分布的卷曲核函数.我们分别考虑了非振动核情形以及振动核情形.对于非振动核情形,我们概述了由Greengard和Rokhlin提出的经典快速多极方法的主要思想.对于振动核情形,我们介绍了最近由Engquist和Ying所发展的定向快速多极方法.

关键词：快速多极方法非振动核振动核多极方法

Neo-intline: integrated pipeline enables neoantigen design through the in-silico presentation of T-cell epitope

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5417-5428页

作者： Bingyu Li Ping Jing Genhui Zheng Chenyu Pi Lu Zhang Zuojing Yin Lijun Xu Jingxuan Qiu Hua Gu Tianyi Qiu Jianmin Fang Laboratory of Molecular Medicine Shanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji HospitalTongji University Suzhou InstituteTongji UniversityShanghaiChina School of Basic Medical Sciences Henan University of Science and TechnologyLuoyangHenanChina Institute of Clinical Science Zhongshan HospitalFudan UniversityShanghaiChina Oden Institute for Computational Engineering and Sciences(ices) University of Texas at AustinAustinTXUSA School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Shanghai Institute of Infectious Disease and Biosecurity Fudan UniversityShanghai200032China

Neoantigen vaccines are one of the most effective immunotherapies for personalized tumour treatment.The current immunogen design of neoantigen vaccines is usually based on whole-genome sequencing(WGS)and bioinformatics prediction that focuses on the prediction of binding affinity between peptide and MHC molecules,ignoring other peptide-presenting related steps.This may result in a gap between high prediction accuracy and relatively low clinical effectiveness.In this study,we designed an integrated in-silico pipeline,Neo-intline,which started from the SNPs and indels of the tumour samples to simulate the presentation process of peptides in-vivo through an integrated calculation model.Validation on the benchmark dataset of TESLA and clinically validated neoantigens illustrated that neo-intline could outperform current state-of-the-art tools on both sample level and melanoma level.Furthermore,by taking the mouse melanoma model as an example,we verified the effectiveness of 20 neoantigens,including 10 MHC-I and 10 MHC-II peptides.The in-vitro and in-vivo experiments showed that both peptides predicted by Neo-intline could recruit corresponding CD4^(+)T cells and CD8^(+)T cells to induce a T-cell-mediated cellular immune response.Moreover,although the therapeutic effect of neoantigen vaccines alone is not sufficient,combinations with other specific therapies,such as broad-spectrum immune-enhanced adjuvants of granulocyte-macrophage colony-stimulating factor(GM-CSF)and polyinosinic-polycytidylic acid(poly(I:C)),or immune checkpoint inhibitors,such as PD-1/PD-L1 antibodies,can illustrate significant anticancer effects on melanoma.Neo-intline can be used as a benchmark process for the design and screening of immunogenic targets for neoantigen vaccines.

关键词： melanoma prediction enable

3D Anisotropic Diffusion on GPUs by Closed-Form Local Tensor Computations

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Numerical Mathematics(Theory,Methods and Applications) 2013年第1期6卷 72-94页

作者： Arjan Kuijper Andreas Schwarzkopf Thomas Kalbe Chandrajit Bajaj Stefan Roth Michael Goesele Fraunhofer IGD 64283 DarmstadtGermany Department of Computer Science TU DarmstadtD-64289 DarmstadtGermany ices-CVC University of Texas at AustinAustinTexas 78712USA.

We present an efficient implementation of volumetric anisotropic image diffusion filters on modern programmable graphics processing units(GPUs),where the mathematics behind volumetric diffusion is effectively reduced to the diffusion in 2D images.We hereby avoid the computational bottleneck of a time consuming eigenvalue decomposition in R3.Instead,we use a projection of the Hessian matrix along the surface normal onto the tangent plane of the local isodensity surface and solve for the remaining two tangent space eigenvectors.We derive closed formulas to achieve this and prevent the GPU code from branching.We show that our most complex volumetric anisotropic diffusion filters gain a speed up of more than 600 compared to a CPU solution.

关键词： Image processing enhancement anisotropic diffusion tensors 3D filtering

Integral Transform Method for a Porous Slider with Magnetic Field and Velocity Slip

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Computer Modeling in Engineering & Sciences 2020年第3期122卷 1099-1118页

作者： Naeem Faraz Yasir Khan Amna Anjum Anwar Hussain International Cultural Exchange School(ices) Donghua UniversityShanghaiChina. Department of Mathematics University of Hafr Al-BatinHafar Al-BatinSaudi Arabia. DBS&HCEME National University of Science and TechnologyIslamabadPakistan.

Current research is about the injection of a viscous fluid in the presence of a transverse uniform magnetic field to reduce the sliding drag.There is a slip-on both the slider and the ground in the two cases,for example,a long porous slider and a circular porous slider.By utilizing similarity transformation Navier-Stokes equations are converted into coupled equations which are tackled by Integral Transform Method.Solutions are obtained for different values of Reynolds numbers,velocity slip,and magnetic field.We found that surface slip and Reynolds number has a substantial influence on the lift and drag of long and circular sliders,whereas the magnetic effect is also noticeable.

关键词： Porous slider MHD flow Reynolds number velocity slip integral transform method.

Stage Division and Pattern Discovery of Complex Patient Care Processes

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Journal of Systems Science & Complexity 2017年第5期30卷 1136-1159页

作者： WANG Tingyan TIAN Xin YU Ming QI Xin YANG Lan Health Care Services Research Center Department of Industrial EngineeringTsinghua UniversityBeijing 100084China Research Center on Fictitious Economy and Data Science Chinese Academy of SciencesBeijing 100190China School of Economics and Management University of Chinese Academy of SciencesBeijing 100190China Health Care Serv-ices Research Center Department of Industrial EngineeringTsinghua UniversityBeijing 100084China

This paper studies the design of a clinical pathway that defines medical service activities within each stage of a patient care process. Much prior research has developed clinical process models that consider the trajectory of services occurring in a care process, by using data mining techniques on process execution logs. A novel approach that provides a more efficient way of clinical pathway design is introduced in this paper. Based on the strategy of TEI@I methodology, the proposed approach integrates statistical methods, optimization techniques and data mining. With the preprocessed data,a complex care process is subsequently divided into several medical stages, and then the patterns of each stage are identified, and thus a clinical pathway is developed. Finally, the proposed method is applied to the real world, using archival data derived from a hospital in Beijing, about three diseases that involve various departments, with an average of 300 samples for each disease. The results of realworld applications demonstrate that the proposed method can automatically and efficiently facilitate clinical pathways design. The main contributions to the field in this paper include(a) a new application of TEI@I methodology in healthcare domain,(b) a novel method for complex processes analysis,(c)tangible evidence of automatic clinical pathways design in the real world.

关键词：临床的小径经常的模式采矿上演分割 TEI@I 虚拟生意

A Numerical Scheme for the Quantum Fokker-Planck-Landau Equation Efficient in the Fluid Regime

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Communications in Computational Physics 2012年第10期12卷 1541-1561页

作者： Jingwei Hu Shi Jin Bokai Yan Institute for Computational Engineering and Sciences(ices) The University of Texas at Austin1 University Station C0200AustinTX 78712USA Department of Mathematics University ofWisconsin-Madison480 Lincoln DriveMadisonWI 53706USA Department of Mathematics and Institute of Natural Sciences Shanghai Jiao Tong UniversityShanghai 200240China

We construct an efficient numerical scheme for the quantum Fokker-Planck-Landau(FPL)equation that works uniformly from kinetic to fluid regimes.Such a scheme inevitably needs an implicit discretization of the nonlinear collision operator,which is difficult to invert.Inspired by work[9]we seek a linear operator to penalize the quantum FPL collision term QqFPL in order to remove the stiffness induced by the small Knudsen number.However,there is no suitable simple quantum operator serving the purpose and for this kind of operators one has to solve the complicated quantum Maxwellians(Bose-Einstein or Fermi-Dirac distribution).In this paper,we propose to penalize QqFPL by the”classical”linear Fokker-Planck operator.It is based on the observation that the classicalMaxwellian,with the temperature replaced by the internal energy,has the same first five moments as the quantum Maxwellian.Numerical results for Bose and Fermi gases are presented to illustrate the efficiency of the scheme in both fluid and kinetic regimes.

关键词： Quantum Fokker-Planck-Landau equation fluid limit asymptotic-preserving scheme

Added Mass Effects in the Design of Partitioned Algorithms for Fluid-Structure Problems with Application to Blood Flows

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Added Mass Effects in the Design of Partitioned Algorithms f...