Opening already occluded middle cerebral artery,internal carotid artery or other cerebral arteries:when,where,how and why?

作     者：David Wang Yongjun Wang 

作者机构：OSF/INI Stroke Network and Comprehensive Stroke CenterOSF Saint Francis Medical CenterPeoriaIllinoisUSA Department of NeurologyUniversity of Illinois College of Medicine at PeoriaPeoriaIllinoisUSA China National Clinical Research Center for Neurological DiseasesBeijingChina Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina 

出 版 物：《Stroke & Vascular Neurology》 (卒中与血管神经病学（英文）)

年 卷 期：2017年第2卷第3期

页      面：106-107页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：cerebral Acute acute 

摘      要：Time is of essence in saving brain cells in patients with acute ischaemic stroke,the faster the treatment,the better the outcome.The time window for intravenous tissue plasminogen activator(tPA)treatment is3 hours.With the recent success of multiple bridging trials,the treatment time window has been opened up to 6-8 hours.In fact,both Therapy in the Treatment of Acute Stroke Due to Anterior Circulation Large Vessel Occlusion Presenting within Eight Hours of Symptom Onset and Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion with Emphasis on Minimizing CT to Recanalization Times trials have treated patients between 8 and 12 hours from the onset.12 We know that the number needed to treat(NNT)to have the benefit for intrave-nous tPA is 1 in 3.In bridging therapy,intra-venous tPA plus intra-arterial thrombectomy within 6 hours of onset,the NNT is 1 in 2-4.